: The Bis(2-ethylhexyl)phthalate (DEHP), a widespread plasticizer, is considered an endocrine disrupting chemical with main toxicological effects on reproductive and metabolic systems. Human biomonitoring (HBM) studies are promoted to evaluate the background exposure levels. In the frame of LIFE PERSUADED project, the HBM study measured DEHP main metabolites (mono-(2-ethylhexyl) phthalate, MEHP; 2-ethyl-5-hydroxy-hexylphthalate, MEHHP; 2-ethyl-5-oxo-hexylphthalate, MEOHP) in Italian children and adolescent (4-14 years old) according to geographical macro-areas and areas, age and sex. Children from the South and the Centre of Italy showed higher median levels of DEHP, as a sum of its metabolites (48.14 and 47.80 μg/L), than those from the North (39.47 μg/L; p = 0.0090 and 0.0004, respectively). Considering the total population, boys are more exposed than girls (only as urinary volume), and children aged 4-6 years have higher median levels than those 7-10 and 11-14 years old. The derived reference values (RV95) for DEHP in children is 168 μg/L. The relative metabolic rates of DEHP, the background levels and, thus, the RV95, vary with the geographical area, age and sex, indicating that all these parameters should be considered in the risk assessment.

Tait, S., Carli, F., Busani, L., Buzzigoli, E., Della Latta, V., Deodati, A., et al. (2020). Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: data from LIFE PERSUADED project. ENVIRONMENTAL RESEARCH, 185 [10.1016/j.envres.2020.109428].

Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: data from LIFE PERSUADED project

Deodati A.;Cianfarani S.;
2020-01-01

Abstract

: The Bis(2-ethylhexyl)phthalate (DEHP), a widespread plasticizer, is considered an endocrine disrupting chemical with main toxicological effects on reproductive and metabolic systems. Human biomonitoring (HBM) studies are promoted to evaluate the background exposure levels. In the frame of LIFE PERSUADED project, the HBM study measured DEHP main metabolites (mono-(2-ethylhexyl) phthalate, MEHP; 2-ethyl-5-hydroxy-hexylphthalate, MEHHP; 2-ethyl-5-oxo-hexylphthalate, MEOHP) in Italian children and adolescent (4-14 years old) according to geographical macro-areas and areas, age and sex. Children from the South and the Centre of Italy showed higher median levels of DEHP, as a sum of its metabolites (48.14 and 47.80 μg/L), than those from the North (39.47 μg/L; p = 0.0090 and 0.0004, respectively). Considering the total population, boys are more exposed than girls (only as urinary volume), and children aged 4-6 years have higher median levels than those 7-10 and 11-14 years old. The derived reference values (RV95) for DEHP in children is 168 μg/L. The relative metabolic rates of DEHP, the background levels and, thus, the RV95, vary with the geographical area, age and sex, indicating that all these parameters should be considered in the risk assessment.
2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
Children exposure; Endocrine disruptors; Reference values; Urinary DEHP metabolites; Adolescent; Biological Monitoring; Child; Child, Preschool; Environmental Exposure; Female; Humans; Italy; Male; Diethylhexyl Phthalate; Phthalic Acids
Tait, S., Carli, F., Busani, L., Buzzigoli, E., Della Latta, V., Deodati, A., et al. (2020). Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: data from LIFE PERSUADED project. ENVIRONMENTAL RESEARCH, 185 [10.1016/j.envres.2020.109428].
Tait, S; Carli, F; Busani, L; Buzzigoli, E; Della Latta, V; Deodati, A; Fabbrizi, E; Gaggini, M; Maranghi, F; Tassinari, R; Toffol, G; Cianfarani, S; Gastaldelli, A; La Rocca, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/294777
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