Cancer immunotherapy represents a major advance in the cure of cancer following the dramatic advancements in the development and refinement of chemotherapies and radiotherapies. In the recent decades, together with the development of early diagnostic techniques, immunotherapy has significantly contributed to improving the survival of cancer patients. The immune-checkpoint blockade agents have been proven effective in a significant fraction of standard therapy refractory patients. Importantly, recent advances are providing alternative immunotherapeutic tools that could help overcome their limitations. In this mini review, we provide an overview on the main steps of the discovery of classic immune-checkpoint blockade agents and summarise the most recent development of novel immunotherapeutic strategies, such as tumour antigens, bispecific antibodies and TCR-engineered T cells.

Sun, Q., Melino, G., Amelio, I., Jiang, J., Wang, Y., Shi, Y. (2021). Recent advances in cancer immunotherapy. DISCOVER ONCOLOGY, 12(1), 27 [10.1007/s12672-021-00422-9].

Recent advances in cancer immunotherapy

Gennaro Melino;Ivano Amelio;
2021-01-01

Abstract

Cancer immunotherapy represents a major advance in the cure of cancer following the dramatic advancements in the development and refinement of chemotherapies and radiotherapies. In the recent decades, together with the development of early diagnostic techniques, immunotherapy has significantly contributed to improving the survival of cancer patients. The immune-checkpoint blockade agents have been proven effective in a significant fraction of standard therapy refractory patients. Importantly, recent advances are providing alternative immunotherapeutic tools that could help overcome their limitations. In this mini review, we provide an overview on the main steps of the discovery of classic immune-checkpoint blockade agents and summarise the most recent development of novel immunotherapeutic strategies, such as tumour antigens, bispecific antibodies and TCR-engineered T cells.
2021
Pubblicato
Rilevanza internazionale
Recensione
Sì, ma tipo non specificato
Settore BIO/11 - BIOLOGIA MOLECOLARE
Settore BIO/10 - BIOCHIMICA
English
Cancer immunotherapy
Cancer survival
Immune check point blockade
KRas
T cell receptor
p53
Sun, Q., Melino, G., Amelio, I., Jiang, J., Wang, Y., Shi, Y. (2021). Recent advances in cancer immunotherapy. DISCOVER ONCOLOGY, 12(1), 27 [10.1007/s12672-021-00422-9].
Sun, Q; Melino, G; Amelio, I; Jiang, J; Wang, Y; Shi, Y
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/294440
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