Background and Aim:Tuberous sclerosis complex (TSC) is associated with a high rate of attention deficit-hyperactivity disorder (ADHD), usually with more severe symptoms than in idiopathic cases. Event-related potentials have been used in idiopathic ADHD, and they have been proposed as a possible biomarker of symptoms severity. Aim of this study was to investigate event-related potential (ERP) characteristics in patients with ADHD secondary to TSC, compared to patients with drug-naive idiopathic ADHD and healthy controls (HCs), to investigate whether (1) distinct clinical features can be due to different pathophysiological mechanisms, and (2) ERPs may reliably predict ADHD symptoms severity in TSC. Materials and Methods:We enrolled 13 patients with idiopathic ADHD (iADHD), 6 patients with ADHD associated with TSC (tscADHD), and 14 age-matched HCs (7-17 years). All of them underwent ERP recording, with mismatch negativity (MMN) preceding the P300 recording. All patients underwent neurocognitive evaluations. Results:Mismatch negativity latency was shorter in iADHD (P= 0.04) and tscADHD (P= 0.06) than in HC, with no difference between patients' groups. Mismatch negativity amplitude was significantly higher in patients (both iADHD and tscADHD) than in HC. The P300 amplitude was significantly lower in iADHD patients than in both tscADHD patients (P= 0.03) and HCs (P< 0.001). No difference was found between tscADHD patients and HCs (P= 0.2). Conclusion:While patients with iADHD present lower P300 amplitude than HC, in tscADHD patients P300 amplitude was not different from that in HC, suggesting that in TSC P300 amplitude does not really reflect symptom severity.

Moavero, R., Marciano, S., Pro, S., De Stefano, D., Vigevano, F., Curatolo, P., et al. (2020). Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity?. FRONTIERS IN NEUROLOGY, 11, 546 [10.3389/fneur.2020.00546].

Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity?

Moavero, Romina;Curatolo, Paolo;Valeriani, Massimiliano
2020-01-01

Abstract

Background and Aim:Tuberous sclerosis complex (TSC) is associated with a high rate of attention deficit-hyperactivity disorder (ADHD), usually with more severe symptoms than in idiopathic cases. Event-related potentials have been used in idiopathic ADHD, and they have been proposed as a possible biomarker of symptoms severity. Aim of this study was to investigate event-related potential (ERP) characteristics in patients with ADHD secondary to TSC, compared to patients with drug-naive idiopathic ADHD and healthy controls (HCs), to investigate whether (1) distinct clinical features can be due to different pathophysiological mechanisms, and (2) ERPs may reliably predict ADHD symptoms severity in TSC. Materials and Methods:We enrolled 13 patients with idiopathic ADHD (iADHD), 6 patients with ADHD associated with TSC (tscADHD), and 14 age-matched HCs (7-17 years). All of them underwent ERP recording, with mismatch negativity (MMN) preceding the P300 recording. All patients underwent neurocognitive evaluations. Results:Mismatch negativity latency was shorter in iADHD (P= 0.04) and tscADHD (P= 0.06) than in HC, with no difference between patients' groups. Mismatch negativity amplitude was significantly higher in patients (both iADHD and tscADHD) than in HC. The P300 amplitude was significantly lower in iADHD patients than in both tscADHD patients (P= 0.03) and HCs (P< 0.001). No difference was found between tscADHD patients and HCs (P= 0.2). Conclusion:While patients with iADHD present lower P300 amplitude than HC, in tscADHD patients P300 amplitude was not different from that in HC, suggesting that in TSC P300 amplitude does not really reflect symptom severity.
2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/39 - NEUROPSICHIATRIA INFANTILE
English
ADHD
ERP
MMN
P300
attention
tuberous sclerosis complex
Moavero, R., Marciano, S., Pro, S., De Stefano, D., Vigevano, F., Curatolo, P., et al. (2020). Event-Related Potentials in ADHD Associated With Tuberous Sclerosis Complex: A Possible Biomarker of Symptoms Severity?. FRONTIERS IN NEUROLOGY, 11, 546 [10.3389/fneur.2020.00546].
Moavero, R; Marciano, S; Pro, S; De Stefano, D; Vigevano, F; Curatolo, P; Valeriani, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/294309
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