This chapter provides an introduction to single-cell electrical characterization techniques and related devices, which play a key role in the framework of label-free biosensing for diagnostics, drug development, and life science. After a brief overview of cell dielectric properties and their modeling using Maxwell Mixture Theory and multi-shell models, three widely used approaches are discussed, namely dielectrophoresis, electrorotation, and microfluidic impedance cytometry. Their basic principles and significance are described, highlighting differences, and common features. Moreover, examples of possible device designs, modes of operation, and applications from recent literature are presented. Finally, emerging trends and expected future developments are discussed.
Cottet, J., Caselli, F. (2021). Single-cell electrical characterization. In Biosensors for Single-Cell Analysis (pp. 71-99). Jian Chen, Yao Lu [10.1016/B978-0-323-89841-6.00008-6].
Single-cell electrical characterization
Caselli, Federica
2021-01-01
Abstract
This chapter provides an introduction to single-cell electrical characterization techniques and related devices, which play a key role in the framework of label-free biosensing for diagnostics, drug development, and life science. After a brief overview of cell dielectric properties and their modeling using Maxwell Mixture Theory and multi-shell models, three widely used approaches are discussed, namely dielectrophoresis, electrorotation, and microfluidic impedance cytometry. Their basic principles and significance are described, highlighting differences, and common features. Moreover, examples of possible device designs, modes of operation, and applications from recent literature are presented. Finally, emerging trends and expected future developments are discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
