mRNA localization and regulated translation play central roles in neurite outgrowth and synaptic plasticity. A key molecule in these processes is the Fragile X mental retardation protein, FMRP, which is involved in the metabolism of neuronal mRNAs. Absence or mutation of FMRP leads to spine dysmorphogenesis and impairs synaptic plasticity. Studies that have mainly been performed on the mouse and Drosophila models for Fragile X Syndrome showed that FMRP is involved in translational regulation at synapses, but even 15 years after discovery of the FMR1 gene, the precise working mechanisms remain elusive.

Zalfa, F., Achsel, T., Bagni, C. (2006). mRNPs, polysomes or granules: FMRP in neuronal protein synthesis. CURRENT OPINION IN NEUROBIOLOGY, 16(3), 265-269 [10.1016/j.conb.2006.05.010].

mRNPs, polysomes or granules: FMRP in neuronal protein synthesis

BAGNI, CLAUDIA
2006-01-01

Abstract

mRNA localization and regulated translation play central roles in neurite outgrowth and synaptic plasticity. A key molecule in these processes is the Fragile X mental retardation protein, FMRP, which is involved in the metabolism of neuronal mRNAs. Absence or mutation of FMRP leads to spine dysmorphogenesis and impairs synaptic plasticity. Studies that have mainly been performed on the mouse and Drosophila models for Fragile X Syndrome showed that FMRP is involved in translational regulation at synapses, but even 15 years after discovery of the FMR1 gene, the precise working mechanisms remain elusive.
2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
fragile X mental retardation protein; messenger ribonucleoprotein; ribonucleoprotein; unclassified drug; fragile X syndrome; human; nerve cell plasticity; nerve fiber growth; nonhuman; polysome; priority journal; protein function; protein synthesis; review; RNA metabolism; RNA translation; synapse; translation initiation; translation regulation; Animals; Brain; Cytoplasmic Granules; Dendritic Spines; Fragile X Mental Retardation Protein; Humans; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Polyribosomes; Protein Biosynthesis; Ribonucleoproteins
Zalfa, F., Achsel, T., Bagni, C. (2006). mRNPs, polysomes or granules: FMRP in neuronal protein synthesis. CURRENT OPINION IN NEUROBIOLOGY, 16(3), 265-269 [10.1016/j.conb.2006.05.010].
Zalfa, F; Achsel, T; Bagni, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/29177
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