The mental retardation protein FMRP is involved in the transport of mRNAs and their translation at synapses. Patients with fragile X syndrome, in whom FMRP is absent or mutated, show deficits in learning and memory that might reflect impairments in the translational regulation of a subset of neuronal mRNAs. The study of FMRP provides important insights into the regulation and functions of local protein synthesis in the neuronal periphery, and increases our understanding of how these functions can produce specific effects at individual synapses.
Bagni, C., & Greenough, W.T. (2005). From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome. NATURE REVIEWS. NEUROSCIENCE, 6(5), 376-387.
Tipologia: | Articolo su rivista |
Citazione: | Bagni, C., & Greenough, W.T. (2005). From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome. NATURE REVIEWS. NEUROSCIENCE, 6(5), 376-387. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/13 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/nrn1667 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2005 |
Titolo: | From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome |
Autori: | |
Autori: | Bagni, C; Greenough, WT |
Appare nelle tipologie: | 01 - Articolo su rivista |