Learning and memory difficulties observed in patients with fragile X syndrome, as well as in a mouse model for the syndrome, are partially due to impaired translational regulation of neuronal mRNAs encoding key molecules for the synaptic structure and function. There has been intense interest in characterizing the mRNAs that are regulated by the fragile X mental retardation protein (FMRP) in the neuronal cell. A large number of candidate FMRP-interacting mRNAs has been identified over the last few years and three models have been described so far to explain the specificity of these interactions. Here, we report our vision on how they could work in the same and/or in different pathways and suggest that the three mechanisms may not be mutually exclusive. © 2004 Lippincott Williams & Wilkins.

Veneri, M., Zalfa, F., Bagni, C. (2004). FMRP and its target RNAs: Fishing for the specificity. NEUROREPORT, 15(16), 2447-2450 [10.1097/00001756-200411150-00002].

FMRP and its target RNAs: Fishing for the specificity

BAGNI, CLAUDIA
2004-01-01

Abstract

Learning and memory difficulties observed in patients with fragile X syndrome, as well as in a mouse model for the syndrome, are partially due to impaired translational regulation of neuronal mRNAs encoding key molecules for the synaptic structure and function. There has been intense interest in characterizing the mRNAs that are regulated by the fragile X mental retardation protein (FMRP) in the neuronal cell. A large number of candidate FMRP-interacting mRNAs has been identified over the last few years and three models have been described so far to explain the specificity of these interactions. Here, we report our vision on how they could work in the same and/or in different pathways and suggest that the three mechanisms may not be mutually exclusive. © 2004 Lippincott Williams & Wilkins.
2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
BC1; Fragile X mental retardation protein; G-quartet; Micro RNAs; Translational regulation
Veneri, M., Zalfa, F., Bagni, C. (2004). FMRP and its target RNAs: Fishing for the specificity. NEUROREPORT, 15(16), 2447-2450 [10.1097/00001756-200411150-00002].
Veneri, M; Zalfa, F; Bagni, C
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/29150
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 9
social impact