Human malignant melanoma shows a high rate of mortality after metastasization, and its incidence is continuously rising worldwide. Several studies have suggested that MCAM/MUC18/CD146 plays an important role in the progression of this malignant disease. MCAM/MUC18/CD146 is a typical single-spanning transmembrane glycoprotein, existing as two membrane isoforms, long and short, and an additional soluble form, sCD146. We previously documented that molecular MCAM/MUC18/CD146 expression is strongly associated with disease progression. Recently, we showed that MCAM/MUC18/CD146 and ABCB5 can serve as melanoma-specific-targets in the selection of highly primitive circulating melanoma cells, and constitute putative proteins associated with disease spreading progression. Here, we analyzed CD146 molecular expression at onset or at disease recurrence in an enlarged melanoma case series. For some patients, we also performed the time courses of molecular monitoring. Moreover, we explored the role of soluble CD146 in different cohorts of melanoma patients at onset or disease progression, rather than in clinical remission, undergoing immune therapy or free from any clinical treatment. We showed that MCAM/MUC18/CD146 can be considered as: (1) a membrane antigen suitable for identification and enrichment in melanoma liquid biopsy; (2) a highly effective molecular "warning " marker for minimal residual disease monitoring; and (3) a soluble protein index of inflammation and putative response to therapeutic treatments.

Rapanotti, M.c., Cugini, E., Nuccetelli, M., Terrinoni, A., Di Raimondo, C., Lombardo, P., et al. (2021). MCAM/MUC18/CD146 as a multifaceted warning marker of melanoma progression in liquid biopsy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), 12416 [10.3390/ijms222212416].

MCAM/MUC18/CD146 as a multifaceted warning marker of melanoma progression in liquid biopsy

Terrinoni A.;Rossi P.;Orlandi A.;Campione E.;Bernardini S.;Bianchi L.
2021-01-01

Abstract

Human malignant melanoma shows a high rate of mortality after metastasization, and its incidence is continuously rising worldwide. Several studies have suggested that MCAM/MUC18/CD146 plays an important role in the progression of this malignant disease. MCAM/MUC18/CD146 is a typical single-spanning transmembrane glycoprotein, existing as two membrane isoforms, long and short, and an additional soluble form, sCD146. We previously documented that molecular MCAM/MUC18/CD146 expression is strongly associated with disease progression. Recently, we showed that MCAM/MUC18/CD146 and ABCB5 can serve as melanoma-specific-targets in the selection of highly primitive circulating melanoma cells, and constitute putative proteins associated with disease spreading progression. Here, we analyzed CD146 molecular expression at onset or at disease recurrence in an enlarged melanoma case series. For some patients, we also performed the time courses of molecular monitoring. Moreover, we explored the role of soluble CD146 in different cohorts of melanoma patients at onset or disease progression, rather than in clinical remission, undergoing immune therapy or free from any clinical treatment. We showed that MCAM/MUC18/CD146 can be considered as: (1) a membrane antigen suitable for identification and enrichment in melanoma liquid biopsy; (2) a highly effective molecular "warning " marker for minimal residual disease monitoring; and (3) a soluble protein index of inflammation and putative response to therapeutic treatments.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
English
MCAM/MUC18/CD146
circulating melanoma cells (CMCs)
gene-expression panel
liquid biopsy
soluble CD146
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
CD146 Antigen
Female
Follow-Up Studies
Humans
Liquid Biopsy
Longitudinal Studies
Male
Melanoma
Middle Aged
Neoplasm Recurrence, Local
Neoplasm, Residual
Neoplastic Cells, Circulating
Skin Neoplasms
Solubility
Young Adult
Disease Progression
Gene Expression
Gene Expression Regulation, Neoplastic
https://www.ncbi.nlm.nih.gov/pubmed/34830300
Rapanotti, M.c., Cugini, E., Nuccetelli, M., Terrinoni, A., Di Raimondo, C., Lombardo, P., et al. (2021). MCAM/MUC18/CD146 as a multifaceted warning marker of melanoma progression in liquid biopsy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), 12416 [10.3390/ijms222212416].
Rapanotti, Mc; Cugini, E; Nuccetelli, M; Terrinoni, A; Di Raimondo, C; Lombardo, P; Costanza, G; Cosio, T; Rossi, P; Orlandi, A; Campione, E; Bernardini, S; Blot-Chabaud, M; Bianchi, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/291452
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