Aim: To evaluate genetic and expression variability of three miRNAs potentially involved in systemic lupus erythematosus (SLE) and to identify any miRNA's target gene. Materials & methods: Gene polymorphisms and expression levels of three miRNAs have been evaluated in a cohort of SLE patients and controls. Results: miR-142 and miR-499a were significantly down-expressed in patients (p = 0.005 and p = 0.02, respectively). A trend for down-expression of miR-155 was also observed (p = 0.07). The lower expression of miR-142 was associated with the rs2632516 polymorphism variant allele (p = 0.002). Predictive analyses identified a target gene common to the three miRNAs, MDM2, whose higher expression was seen in patients compared with controls (p = 0.03). Conclusion: The three miRNAs and MDM2 might be involved in SLE.

Latini, A., Ciccacci, C., De Benedittis, G., Novelli, L., Ceccarelli, F., Conti, F., et al. (2021). Altered expression of miR-142, miR-155, miR-499a and of their putative common target MDM2 in systemic lupus erythematosus. EPIGENOMICS, 13(1), 5-13 [10.2217/epi-2020-0278].

Altered expression of miR-142, miR-155, miR-499a and of their putative common target MDM2 in systemic lupus erythematosus

Ciccacci C.;Novelli G.;Borgiani P.
2021

Abstract

Aim: To evaluate genetic and expression variability of three miRNAs potentially involved in systemic lupus erythematosus (SLE) and to identify any miRNA's target gene. Materials & methods: Gene polymorphisms and expression levels of three miRNAs have been evaluated in a cohort of SLE patients and controls. Results: miR-142 and miR-499a were significantly down-expressed in patients (p = 0.005 and p = 0.02, respectively). A trend for down-expression of miR-155 was also observed (p = 0.07). The lower expression of miR-142 was associated with the rs2632516 polymorphism variant allele (p = 0.002). Predictive analyses identified a target gene common to the three miRNAs, MDM2, whose higher expression was seen in patients compared with controls (p = 0.03). Conclusion: The three miRNAs and MDM2 might be involved in SLE.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03
English
MDM2
expression study
lupus erythematosus systemic
miRNAs
polymorphisms
Case-Control Studies
Cohort Studies
Female
Gene Expression
Humans
Lupus Erythematosus, Systemic
Male
MicroRNAs
Polymorphism, Genetic
Proto-Oncogene Proteins c-mdm2
Latini, A., Ciccacci, C., De Benedittis, G., Novelli, L., Ceccarelli, F., Conti, F., et al. (2021). Altered expression of miR-142, miR-155, miR-499a and of their putative common target MDM2 in systemic lupus erythematosus. EPIGENOMICS, 13(1), 5-13 [10.2217/epi-2020-0278].
Latini, A; Ciccacci, C; De Benedittis, G; Novelli, L; Ceccarelli, F; Conti, F; Novelli, G; Perricone, C; Borgiani, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/290326
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