Among 470 patients with acquired immune deficiency syndrome and/or human immunodeficiency virus infection (HIV/AIDS) who underwent genotype resistance testing (GRT) after the failure of therapy, 17 (3.6%) harbored the Q151M mutation. The Q151M mutation was associated with younger age, lower CD4(+) lymphocyte count, higher HIV RNA level, and treatment with >2 pre-GRT regimens. By contrast, the Q151M mutation was inversely associated with lamivudine administration. A full reversion of the Q151M mutation was observed in 5 of 5 patients who underwent treatment interruption after GRT. The reversion was followed by a response to salvage therapy in 4 (80%) of 5 patients.

Zaccarelli, M., Perno, C.f., Forbici, F., Soldani, F., Bonfigli, S., Gori, C., et al. (2004). Q151M-mediated multinucleoside resistance: prevalence, risk factors, and response to salvage therapy. CLINICAL INFECTIOUS DISEASES, 38(3), 433-437 [10.1086/381097].

Q151M-mediated multinucleoside resistance: prevalence, risk factors, and response to salvage therapy

PERNO, CARLO FEDERICO;Bellocchi, M;
2004-02-01

Abstract

Among 470 patients with acquired immune deficiency syndrome and/or human immunodeficiency virus infection (HIV/AIDS) who underwent genotype resistance testing (GRT) after the failure of therapy, 17 (3.6%) harbored the Q151M mutation. The Q151M mutation was associated with younger age, lower CD4(+) lymphocyte count, higher HIV RNA level, and treatment with >2 pre-GRT regimens. By contrast, the Q151M mutation was inversely associated with lamivudine administration. A full reversion of the Q151M mutation was observed in 5 of 5 patients who underwent treatment interruption after GRT. The reversion was followed by a response to salvage therapy in 4 (80%) of 5 patients.
1-feb-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Glutamine; Humans; Salvage Therapy; Lamivudine; HIV-1; Methionine; Reverse Transcriptase Inhibitors; Multivariate Analysis; Drug Resistance, Multiple; HIV Infections; Risk Factors; Adult; HIV Reverse Transcriptase; Microbial Sensitivity Tests; Female; Male; Prevalence
Zaccarelli, M., Perno, C.f., Forbici, F., Soldani, F., Bonfigli, S., Gori, C., et al. (2004). Q151M-mediated multinucleoside resistance: prevalence, risk factors, and response to salvage therapy. CLINICAL INFECTIOUS DISEASES, 38(3), 433-437 [10.1086/381097].
Zaccarelli, M; Perno, Cf; Forbici, F; Soldani, F; Bonfigli, S; Gori, C; Trotta, M; Bellocchi, M; Liuzzi, G; D'Arrigo, R; De Longis, P; Boumis, E; Bell...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/29019
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