Monocytes/Macrophages (M/M) play a pivotal role as a source of virus during the whole course of HIV-1 infection. Enhanced oxidative stress is involved in the pathogenesis of HIV-1 infection. HIV-1 regulatory proteins induce a reduction of the expression and the activity of MnSOD, the mitochondrial isoform leading to a sustained generation of superoxide anions and peroxynitrite that represent important mediators of HIV-1 replication in M/M. MnTBAP (Mn(III)tetrakis(4-benzoic acid)porphrin chloride), a synthetic peroxynitrite decomposition catalyst, reduced oxidative stress subsequent to peroxynitrite generation.
Aquaro, S., Muscoli, C., Ranazzi, A., Pollicita, M., Granato, T., Masuelli, L., et al. (2007). The contribution of peroxynitrite generation in HIV replication in human primary macrophages. RETROVIROLOGY, 4, 76-76 [10.1186/1742-4690-4-76].
The contribution of peroxynitrite generation in HIV replication in human primary macrophages
AQUARO, STEFANO;POLLICITA, MICHELA;MODESTI, ANDREA;PERNO, CARLO FEDERICO;MOLLACE, VINCENZO
2007-01-01
Abstract
Monocytes/Macrophages (M/M) play a pivotal role as a source of virus during the whole course of HIV-1 infection. Enhanced oxidative stress is involved in the pathogenesis of HIV-1 infection. HIV-1 regulatory proteins induce a reduction of the expression and the activity of MnSOD, the mitochondrial isoform leading to a sustained generation of superoxide anions and peroxynitrite that represent important mediators of HIV-1 replication in M/M. MnTBAP (Mn(III)tetrakis(4-benzoic acid)porphrin chloride), a synthetic peroxynitrite decomposition catalyst, reduced oxidative stress subsequent to peroxynitrite generation.Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons
