Monocytes/Macrophages (M/M) play a pivotal role as a source of virus during the whole course of HIV-1 infection. Enhanced oxidative stress is involved in the pathogenesis of HIV-1 infection. HIV-1 regulatory proteins induce a reduction of the expression and the activity of MnSOD, the mitochondrial isoform leading to a sustained generation of superoxide anions and peroxynitrite that represent important mediators of HIV-1 replication in M/M. MnTBAP (Mn(III)tetrakis(4-benzoic acid)porphrin chloride), a synthetic peroxynitrite decomposition catalyst, reduced oxidative stress subsequent to peroxynitrite generation.

Aquaro, S., Muscoli, C., Ranazzi, A., Pollicita, M., Granato, T., Masuelli, L., et al. (2007). The contribution of peroxynitrite generation in HIV replication in human primary macrophages, 4, 76-76 [10.1186/1742-4690-4-76].

The contribution of peroxynitrite generation in HIV replication in human primary macrophages

AQUARO, STEFANO;POLLICITA, MICHELA;MODESTI, ANDREA;PERNO, CARLO FEDERICO;MOLLACE, VINCENZO
2007-01-01

Abstract

Monocytes/Macrophages (M/M) play a pivotal role as a source of virus during the whole course of HIV-1 infection. Enhanced oxidative stress is involved in the pathogenesis of HIV-1 infection. HIV-1 regulatory proteins induce a reduction of the expression and the activity of MnSOD, the mitochondrial isoform leading to a sustained generation of superoxide anions and peroxynitrite that represent important mediators of HIV-1 replication in M/M. MnTBAP (Mn(III)tetrakis(4-benzoic acid)porphrin chloride), a synthetic peroxynitrite decomposition catalyst, reduced oxidative stress subsequent to peroxynitrite generation.
2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Virus Replication; Macrophages; HIV Infections; Cells, Cultured; Humans; Peroxynitrous Acid; HIV-1; Metalloporphyrins
Aquaro, S., Muscoli, C., Ranazzi, A., Pollicita, M., Granato, T., Masuelli, L., et al. (2007). The contribution of peroxynitrite generation in HIV replication in human primary macrophages, 4, 76-76 [10.1186/1742-4690-4-76].
Aquaro, S; Muscoli, C; Ranazzi, A; Pollicita, M; Granato, T; Masuelli, L; Modesti, A; Perno, Cf; Mollace, V
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons Creative Commons

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/28984
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 27
social impact