Transmission of drug-resistant HIV-1 variants has been increasingly documented. The most commonly observed resistance-associated mutations are thymidine analogue mutations as well as non-nucleoside reverse transcriptase inhibitor mutations. We report on a case of secondary transmission of a protease inhibitor (PI) primary mutation from an infected untreated subject to his sexual partner. Sequences isolated from the 2 patients showed a high level of identity (>99%), both carrying the major IAS PI mutation M46I. The latter mutation persisted in the bloodstream of the female partner 1 year after its first detection.
Polilli, E., Di Masi, F., Sozio, F., Mazzotta, E., Alterio, L., Cosentino, L., et al. (2009). Sequential transmission and long-term persistence of an HIV strain partially resistant to protease inhibitors. NEW MICROBIOLOGICA, 32(2), 205-208.
Sequential transmission and long-term persistence of an HIV strain partially resistant to protease inhibitors
PERNO, CARLO FEDERICO;
2009-04-01
Abstract
Transmission of drug-resistant HIV-1 variants has been increasingly documented. The most commonly observed resistance-associated mutations are thymidine analogue mutations as well as non-nucleoside reverse transcriptase inhibitor mutations. We report on a case of secondary transmission of a protease inhibitor (PI) primary mutation from an infected untreated subject to his sexual partner. Sequences isolated from the 2 patients showed a high level of identity (>99%), both carrying the major IAS PI mutation M46I. The latter mutation persisted in the bloodstream of the female partner 1 year after its first detection.Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons
