Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators of ovarian function including the formation of the germ cell precursors, termed primordial germ cells, and the follicular pool maintenance. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/AKT pathways during primordial germ cell development and the dynamics of the ovarian primordial follicle reserve and how dysregulation of these signaling pathways may contribute to the development of some types of germ cell tumors and ovarian dysfunctions.

De Felici, M., Klinger, F.g. (2021). Pi3k/pten/akt signaling pathways in germ cell development and their involvement in germ cell tumors and ovarian dysfunctions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(18), 9838 [10.3390/ijms22189838].

Pi3k/pten/akt signaling pathways in germ cell development and their involvement in germ cell tumors and ovarian dysfunctions

De Felici M.
;
Klinger F. G.
2021-01-01

Abstract

Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators of ovarian function including the formation of the germ cell precursors, termed primordial germ cells, and the follicular pool maintenance. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/AKT pathways during primordial germ cell development and the dynamics of the ovarian primordial follicle reserve and how dysregulation of these signaling pathways may contribute to the development of some types of germ cell tumors and ovarian dysfunctions.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/17 - ISTOLOGIA
English
PI3K/PTEN/AKT
germ cell tumors
ovarian dysfunction
ovarian follicles
ovarian reserve
primordial follicles
primordial germ cells
Germ Cells
Ovarian Diseases
PTEN Phosphohydrolase
Phosphatidylinositol 3-Kinases
De Felici, M., Klinger, F.g. (2021). Pi3k/pten/akt signaling pathways in germ cell development and their involvement in germ cell tumors and ovarian dysfunctions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(18), 9838 [10.3390/ijms22189838].
De Felici, M; Klinger, Fg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/286402
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