Colorectal cancer (CRC) is a serious complication of inflammatory bowel disease (IBD). Although conclusive evidence is still missing, epidemiological and preliminary clinical work strongly suggests that mesalazine may have chemopreventive properties against IBD-related CRC. Therefore, in recent years, several experimental studies have been conducted to dissect the mechanism(s) by which mesalazine interferes with CRC cell growth and survival. This review summarizes the current information on the molecular pathways that are regulated by mesalazine in CRC. © 2008 Bentham Science Publishers Ltd.

Stolfi, C., Pellegrini, R., Pallone, F., Monteleorte, G. (2008). Molecular targets of mesalazine in colorectal cancer. CURRENT CANCER THERAPY REVIEWS, 4(4), 262-266 [10.2174/157339408786413326].

Molecular targets of mesalazine in colorectal cancer

Stolfi C.;PALLONE, FRANCESCO;
2008-01-01

Abstract

Colorectal cancer (CRC) is a serious complication of inflammatory bowel disease (IBD). Although conclusive evidence is still missing, epidemiological and preliminary clinical work strongly suggests that mesalazine may have chemopreventive properties against IBD-related CRC. Therefore, in recent years, several experimental studies have been conducted to dissect the mechanism(s) by which mesalazine interferes with CRC cell growth and survival. This review summarizes the current information on the molecular pathways that are regulated by mesalazine in CRC. © 2008 Bentham Science Publishers Ltd.
2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
mesalazine; cancer growth; cell survival; chemoprophylaxis; colorectal cancer; drug mechanism; enteritis; experimental study; human; nonhuman; priority journal; review
Stolfi, C., Pellegrini, R., Pallone, F., Monteleorte, G. (2008). Molecular targets of mesalazine in colorectal cancer. CURRENT CANCER THERAPY REVIEWS, 4(4), 262-266 [10.2174/157339408786413326].
Stolfi, C; Pellegrini, R; Pallone, F; Monteleorte, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/28607
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