Highly oxidized lignans produced during the cytochrome P-450 metabolism in the cells show biological activities significantly different from those of their parent natural compounds. Lignans precursors of mammalian enterolignans were treated with a methyltrioxorhenium/hydrogen peroxide catalytic system to afford new compounds oxidized at benzylic as well as in arylic positions. The evaluation of the antioxidant and apoptogenic activity by in vivo protocols of these compounds showed some interesting structure-activity relationships related to the oxidation degree of the molecules. (C) 2009 Elsevier Ltd. All rights reserved.

Bernini, R., Gualandi, G., Crestini, C., Barontini, M., Belfiore, M., Willfor, S., et al. (2009). A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity. BIOORGANIC & MEDICINAL CHEMISTRY, 17(15), 5676-5682 [10.1016/j.bmc.2009.06.010].

A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity

CRESTINI, CLAUDIA;
2009-01-01

Abstract

Highly oxidized lignans produced during the cytochrome P-450 metabolism in the cells show biological activities significantly different from those of their parent natural compounds. Lignans precursors of mammalian enterolignans were treated with a methyltrioxorhenium/hydrogen peroxide catalytic system to afford new compounds oxidized at benzylic as well as in arylic positions. The evaluation of the antioxidant and apoptogenic activity by in vivo protocols of these compounds showed some interesting structure-activity relationships related to the oxidation degree of the molecules. (C) 2009 Elsevier Ltd. All rights reserved.
2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/03 - CHIMICA GENERALE E INORGANICA
English
Con Impact Factor ISI
Antioxidant activity; Apoptogenic activity; Lignans; Methyltrioxorhenium; Oxidation
Bernini, R., Gualandi, G., Crestini, C., Barontini, M., Belfiore, M., Willfor, S., et al. (2009). A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity. BIOORGANIC & MEDICINAL CHEMISTRY, 17(15), 5676-5682 [10.1016/j.bmc.2009.06.010].
Bernini, R; Gualandi, G; Crestini, C; Barontini, M; Belfiore, M; Willfor, S; Eklund, P; Saladino, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/28468
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