Aerobic training is known to influence cognitive processes, such as memory and learning, both in animal models and in humans. Particularly, in vitro and in vivo studies have shown that aerobic exercise can increase neurogenesis in the dentate gyrus, improve hippocampal long-term potentiation (LTP), and reduce age-related decline in mnemonic function. However, the underlying mechanisms are not yet fully understood. Based on this evidence, the aim of our study was to verify whether the application of two aerobic training protocols, different in terms of speed and speed variation, could modulate synaptic plasticity in a young murine model. Therefore, we assessed the presence of any functional changes by extracellular recordings in vitro in mouse hippocampal slices and structural alterations by transmission electron microscopy (TEM). Our results showed that an aerobic training protocol, well designed in terms of speed and speed variation, significantly contributes to improving synaptic plasticity and hippocampal ultrastructure, optimizing its benefits in the brain. Future studies will aim to clarify the underlying biological mechanisms involved in the modulation of synaptic plasticity induced by aerobic training.

Cariati, I., Bonanni, R., Pallone, G., Scimeca, M., Frank, C., Tancredi, V., et al. (2021). Hippocampal Adaptations to Continuous Aerobic Training: A Functional and Ultrastructural Evaluation in a Young Murine Model. JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY [10.3390/jfmk6040101].

Hippocampal Adaptations to Continuous Aerobic Training: A Functional and Ultrastructural Evaluation in a Young Murine Model

Ida Cariati
;
Manuel Scimeca;Virginia Tancredi;Giovanna D'Arcangelo
2021-01-01

Abstract

Aerobic training is known to influence cognitive processes, such as memory and learning, both in animal models and in humans. Particularly, in vitro and in vivo studies have shown that aerobic exercise can increase neurogenesis in the dentate gyrus, improve hippocampal long-term potentiation (LTP), and reduce age-related decline in mnemonic function. However, the underlying mechanisms are not yet fully understood. Based on this evidence, the aim of our study was to verify whether the application of two aerobic training protocols, different in terms of speed and speed variation, could modulate synaptic plasticity in a young murine model. Therefore, we assessed the presence of any functional changes by extracellular recordings in vitro in mouse hippocampal slices and structural alterations by transmission electron microscopy (TEM). Our results showed that an aerobic training protocol, well designed in terms of speed and speed variation, significantly contributes to improving synaptic plasticity and hippocampal ultrastructure, optimizing its benefits in the brain. Future studies will aim to clarify the underlying biological mechanisms involved in the modulation of synaptic plasticity induced by aerobic training.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/09 - FISIOLOGIA
English
Con Impact Factor ISI
amyloid; neurodegeneration; prefibrillar oligomers; structure; membrane permeabilization; Ca2+ influx; neurotoxicity; synaptic transmission; long-term potentiation
Cariati, I., Bonanni, R., Pallone, G., Scimeca, M., Frank, C., Tancredi, V., et al. (2021). Hippocampal Adaptations to Continuous Aerobic Training: A Functional and Ultrastructural Evaluation in a Young Murine Model. JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY [10.3390/jfmk6040101].
Cariati, I; Bonanni, R; Pallone, G; Scimeca, M; Frank, C; Tancredi, V; D'Arcangelo, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/284450
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