Lichen sclerosus (LS) is a disabling chronic inflammatory disease of skin and genital mucous membrane causing itch, pain, dysuria and restriction of micturition, and significant sexual dysfunction and dyspareunia both in women and men. If left untreated, LS is associated with a high degree of sclerosis and scarring, as well as with an elevated risk of cancer in the genital area. Although a central role of autoimmunity is suggested, the pathogenesis of LS is still not clearly understood and the disease remains difficult to treat. The goals of treatment of LS are to alleviate symptoms and discomfort, prevent anatomical changes and prevent malignant transformation. This guideline has been developed by an Italian group of experts. It summarizes evidence-based and expert-based recommendations. The highest level of evidence favors the use of topical high potency corticosteroids; second-and third-line treatments include topical calcineurin inhibitors and topical retinoids, respectively. Surgical treatment has become the treatment of choice in male genital LS with persistent phimosis not responsive to medical treatment. The aim of this paper is to offer evidence-based and easily applicable recommendations for the management of LS.

Papini, M., Russo, A., Simonetti, O., Borghi, A., Corazza, M., Piaserico, S., et al. (2021). Diagnosis and management of cutaneous and anogenital lichen sclerosus: Recommendations from the Italian Society of Dermatology (SIDemaSt). ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY, 156(2), 519-533 [10.23736/S2784-8671.21.06764-X].

Diagnosis and management of cutaneous and anogenital lichen sclerosus: Recommendations from the Italian Society of Dermatology (SIDemaSt)

Campione E.;Galluzzo M.;Talamonti M.;
2021-01-01

Abstract

Lichen sclerosus (LS) is a disabling chronic inflammatory disease of skin and genital mucous membrane causing itch, pain, dysuria and restriction of micturition, and significant sexual dysfunction and dyspareunia both in women and men. If left untreated, LS is associated with a high degree of sclerosis and scarring, as well as with an elevated risk of cancer in the genital area. Although a central role of autoimmunity is suggested, the pathogenesis of LS is still not clearly understood and the disease remains difficult to treat. The goals of treatment of LS are to alleviate symptoms and discomfort, prevent anatomical changes and prevent malignant transformation. This guideline has been developed by an Italian group of experts. It summarizes evidence-based and expert-based recommendations. The highest level of evidence favors the use of topical high potency corticosteroids; second-and third-line treatments include topical calcineurin inhibitors and topical retinoids, respectively. Surgical treatment has become the treatment of choice in male genital LS with persistent phimosis not responsive to medical treatment. The aim of this paper is to offer evidence-based and easily applicable recommendations for the management of LS.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/35
English
Lichen sclerosus et atrophicus
Vulvar lichen sclerosus
Rare diseases
Guideline
Drug therapy
Operative surgical procedures
Calcineurin Inhibitors
Female
Humans
Italy
Male
Mometasone Furoate
Dermatology
Lichen Sclerosus et Atrophicus
Papini, M., Russo, A., Simonetti, O., Borghi, A., Corazza, M., Piaserico, S., et al. (2021). Diagnosis and management of cutaneous and anogenital lichen sclerosus: Recommendations from the Italian Society of Dermatology (SIDemaSt). ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY, 156(2), 519-533 [10.23736/S2784-8671.21.06764-X].
Papini, M; Russo, A; Simonetti, O; Borghi, A; Corazza, M; Piaserico, S; Feliciani, C; Calzavara-Pinton, P; Amendolagine, G; Arisi, M; Babino, G; Bardazzi, F; Belloni Fortina, A; Cac-Cavale, S; Campanati, A; Campione, E; Caposiena, Cd; Carugno, A; Coati, I; Cinotti, E; D'Antuono, A; Dattola, A; Dika, E; Fai, D; Fusano, M; Galluzzo, M; Ganzetti, G; Gisondi, P; Hansel, K; Lora, V; Maione, V; Mandel, Vd; Menni, S; Negosanti, M; Neri, I; Offidani, A; Parodi, A; Patrizi, A; Peserico, A; Rossi, M; Rivetti, N; Saccani, E; Stan, Tr; Stingeni, L; Talamonti, M; Vascellaro, A; Vezzoli, P; Virgili, A; Zanca, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/284054
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