In Parkinson’s disease, the subthalamic nucleus (STN) is a common target for functional neurosurgery. Recent investigations have suggested that physiological non-motor stimuli may dramatically alter STN firing properties. By maintaining long-lasting micro-recordings of STN single units in Parkinson’s disease(PD) patients, here we show that the neurons that are responsive to passive movements are also strongly modulated by altered vigilance state (awake vs. sleep). In addition, sleep was characterized by a distinctive irregular train-like firing pattern. These findings suggest that the reduction of the somato-sensory input modifies rigidity and, hence, STN discharge mode. Further, it is suggested that specific STN electrophysiological features are potential targets for future therapeutic interventions

Stefani, A., Galati, S., Peppe, A., Bassi, A., Pierantozzi, M., Hainsworth, A., et al. (2006). Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus. EXPERIMENTAL BRAIN RESEARCH, 168(1-2), 277-280 [10.1007/s00221-005-0175-y].

Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus

STEFANI, ALESSANDRO;PIERANTOZZI, MARIANGELA;BERNARDI, GIORGIO;ORLACCHIO, ANTONIO;STANZIONE, PAOLO;
2006-01-01

Abstract

In Parkinson’s disease, the subthalamic nucleus (STN) is a common target for functional neurosurgery. Recent investigations have suggested that physiological non-motor stimuli may dramatically alter STN firing properties. By maintaining long-lasting micro-recordings of STN single units in Parkinson’s disease(PD) patients, here we show that the neurons that are responsive to passive movements are also strongly modulated by altered vigilance state (awake vs. sleep). In addition, sleep was characterized by a distinctive irregular train-like firing pattern. These findings suggest that the reduction of the somato-sensory input modifies rigidity and, hence, STN discharge mode. Further, it is suggested that specific STN electrophysiological features are potential targets for future therapeutic interventions
gen-2006
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
DBS; basal ganglia; firing pattern; Parkinson’s disease; vigilance
Stefani, A., Galati, S., Peppe, A., Bassi, A., Pierantozzi, M., Hainsworth, A., et al. (2006). Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus. EXPERIMENTAL BRAIN RESEARCH, 168(1-2), 277-280 [10.1007/s00221-005-0175-y].
Stefani, A; Galati, S; Peppe, A; Bassi, A; Pierantozzi, M; Hainsworth, A; Bernardi, G; Orlacchio, A; Stanzione, P; Mazzone, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/28367
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