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EnglishPurpose of Review The regenerative capacity of the heart is insufficient to compensate for the pathological loss of cardiomyocytes during a large injury, such as a myocardial infarction. Therapeutic options for patients after cardiac infarction are limited: treatment with drugs that only treat the symptoms or extraordinary measures, such as heart transplantation. Cell therapies offer a promising strategy for cardiac regeneration. In this brief review, the major issues in these areas are discussed, and possible directions for future research are indicated. Recent Findings Cardiac regeneration can be obtained by at least two strategies: the first is direct to generate an ex vivo functional myocardial tissue that replaces damaged tissue; the second approach aims to stimulate endogenous mechanisms of cardiac repair. However, current cell therapies are still hampered by poor translation into actual clinical applications. In this scenario, recent advancements in cell biology and biomaterial-based technologies can play a key role to design effective therapeutic approaches.
Carotenuto, F., Manzari, V., & Di Nardo, P. (2021). Cardiac Regeneration: the Heart of the Issue. CURRENT TRANSPLANTATION REPORTS, 8(2), 67-75 [10.1007/s40472-021-00319-0].
| Tipologia: | Articolo su rivista | |
| Citazione: | Carotenuto, F., Manzari, V., & Di Nardo, P. (2021). Cardiac Regeneration: the Heart of the Issue. CURRENT TRANSPLANTATION REPORTS, 8(2), 67-75 [10.1007/s40472-021-00319-0]. | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore MED/50 Settore MED/46 Settore BIO/13 | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Recensione | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s40472-021-00319-0 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 23-mar-2021 | |
| Titolo: | Cardiac Regeneration: the Heart of the Issue | |
| Autori: | ||
| Autori: | Carotenuto, F; Manzari, V; Di Nardo, P | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Carotenuto et al_Cardiac Regeneration Issue_REV_2021.pdf | Versione Editoriale (PDF) |  | Open Access Visualizza/Apri |
http://hdl.handle.net/2108/283366
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