fatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health disparities, particularly in the united States, as a result of cultural eating habits and lifestyle. Pathological studies on NAFLD have been mostly focused on hepatocytes and other inflammatory cell types; however, the impact of other biliary epithelial cells (i.e., cholangiocytes) in the promotion of NAFLD is growing. this review article will discuss how cholestatic injury and cholangiocyte activity/ductular reaction influence NAFLD progression. furthermore, this review will provide informative details regarding the fundamental properties of cholangiocytes and bile acid signaling that can influence NAFLD. lastly, studies relating to the pathogenesis of NAFLD, cholangiopathies, and ductular reaction will be analyzed to help gain insight for potential therapies.

Zhou, T., Kundu, D., Robles-Linares, J., Meadows, V., Sato, K., Baiocchi, L., et al. (2021). Feedback signaling between cholangiopathies, ductular reaction, and non-alcoholic fatty liver disease. CELLS, 10(8), 2072 [10.3390/cells10082072].

Feedback signaling between cholangiopathies, ductular reaction, and non-alcoholic fatty liver disease

Baiocchi, Leonardo;
2021-01-01

Abstract

fatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health disparities, particularly in the united States, as a result of cultural eating habits and lifestyle. Pathological studies on NAFLD have been mostly focused on hepatocytes and other inflammatory cell types; however, the impact of other biliary epithelial cells (i.e., cholangiocytes) in the promotion of NAFLD is growing. this review article will discuss how cholestatic injury and cholangiocyte activity/ductular reaction influence NAFLD progression. furthermore, this review will provide informative details regarding the fundamental properties of cholangiocytes and bile acid signaling that can influence NAFLD. lastly, studies relating to the pathogenesis of NAFLD, cholangiopathies, and ductular reaction will be analyzed to help gain insight for potential therapies.
2021
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore MED/12 - GASTROENTEROLOGIA
Settore MEDS-10/A - Gastroenterologia
English
Con Impact Factor ISI
bile acids; cholangiocytes; cholestatic liver disease; ductular reaction; non-alcoholic fatty liver disease; Bile Ducts;
Bile Acids and Salts, Cannabinoids; Cholestasis; Epithelial Cells ; Humans; Neurosecretory Systems
Non-alcoholic Fatty Liver Disease; Vascular Endothelial Growth Factor A; Signal Transduction
Zhou, T., Kundu, D., Robles-Linares, J., Meadows, V., Sato, K., Baiocchi, L., et al. (2021). Feedback signaling between cholangiopathies, ductular reaction, and non-alcoholic fatty liver disease. CELLS, 10(8), 2072 [10.3390/cells10082072].
Zhou, T; Kundu, D; Robles-Linares, J; Meadows, V; Sato, K; Baiocchi, L; Ekser, B; Glaser, S; Alpini, G; Francis, H; Kennedy, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/282380
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