The identification of microRNAs in biological fluids for diagnosis and prognosis is receiving great attention in the field of multiple sclerosis (MS) research but it is still in its infancy. In the present study, we observed in a large sample of MS patients that let-7b-5p levels in the cerebrospinal fluid (CSF) were highly correlated with a number of microRNAs implicated in MS, as well as with a variety of inflammation-related protein factors, showing specific expression patterns coherent with let-7b-5p-mediated regulation. Additionally, we found that the CSF let-7b-5p levels were significantly reduced in patients with the progressive MS compared to patients with relapsing-remitting MS and were negatively correlated with characteristic hallmark processes of the two phases of the disease. Indeed, in the non-progressive phase, let-7b-5p inversely associated with both central and peripheral inflammation; whereas, in progressive MS, the CSF levels of let-7b-5p negatively correlated with clinical disability at disease onset and after a follow-up period. Overall, our results uncovered, by the means of a multidisciplinary approach and multiple statistical analyses, a new possible pleiotropic action of let-7b-5p in MS, with potential utility as a biomarker of MS course.

Mandolesi, G., Rizzo, F.R., Balletta, S., Stampanoni Bassi, M., Gilio, L., Guadalupi, L., et al. (2021). The microRNA let-7b-5p Is Negatively Associated with Inflammation and Disease Severity in Multiple Sclerosis. CELLS, 10(2), 1-22 [10.3390/cells10020330].

The microRNA let-7b-5p Is Negatively Associated with Inflammation and Disease Severity in Multiple Sclerosis

Rizzo, Francesca Romana;Moscatelli, Alessandro;Musella, Alessandra;Gentile, Antonietta;Fresegna, Diego;Bullitta, Silvia;Caioli, Silvia;Vanni, Valentina;Bruno, Antonio;Buttari, Fabio;Centonze, Diego;
2021

Abstract

The identification of microRNAs in biological fluids for diagnosis and prognosis is receiving great attention in the field of multiple sclerosis (MS) research but it is still in its infancy. In the present study, we observed in a large sample of MS patients that let-7b-5p levels in the cerebrospinal fluid (CSF) were highly correlated with a number of microRNAs implicated in MS, as well as with a variety of inflammation-related protein factors, showing specific expression patterns coherent with let-7b-5p-mediated regulation. Additionally, we found that the CSF let-7b-5p levels were significantly reduced in patients with the progressive MS compared to patients with relapsing-remitting MS and were negatively correlated with characteristic hallmark processes of the two phases of the disease. Indeed, in the non-progressive phase, let-7b-5p inversely associated with both central and peripheral inflammation; whereas, in progressive MS, the CSF levels of let-7b-5p negatively correlated with clinical disability at disease onset and after a follow-up period. Overall, our results uncovered, by the means of a multidisciplinary approach and multiple statistical analyses, a new possible pleiotropic action of let-7b-5p in MS, with potential utility as a biomarker of MS course.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26
eng
Con Impact Factor ISI
Expanded Disability Status Scale (EDSS)
G_CSF
IL5
RANTES
inflammation
let-7
miRNAs
multiple sclerosis (MS)
progressive multiple sclerosis (PMS)
Adult
Female
Humans
Inflammation
Male
MicroRNAs
Middle Aged
Multiple Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915741/pdf/cells-10-00330.pdf
Mandolesi, G., Rizzo, F.R., Balletta, S., Stampanoni Bassi, M., Gilio, L., Guadalupi, L., et al. (2021). The microRNA let-7b-5p Is Negatively Associated with Inflammation and Disease Severity in Multiple Sclerosis. CELLS, 10(2), 1-22 [10.3390/cells10020330].
Mandolesi, G; Rizzo, Fr; Balletta, S; Stampanoni Bassi, M; Gilio, L; Guadalupi, L; Nencini, M; Moscatelli, A; Ryan, Cp; Licursi, V; Dolcetti, E; Musella, A; Gentile, A; Fresegna, D; Bullitta, S; Caioli, S; Vanni, V; Sanna, K; Bruno, A; Buttari, F; Castelli, C; Presutti, C; De Santa, F; Finardi, A; Furlan, R; Centonze, D; De Vito, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/282348
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