: Age at onset is the main risk factor for disease progression in patients with relapsing-remitting multiple sclerosis (RR-MS). In this cross-sectional study, we explored whether older age is associated with specific disease features involved in the progression independent of relapse activity (PIRA). In 266 patients with RR-MS, the associations between age at onset, clinical characteristics, cerebrospinal fluid (CSF) levels of lactate, and that of several inflammatory molecules were analyzed. The long-term potentiation (LTP)-like plasticity was studied using transcranial magnetic stimulation (TMS). Older age was associated with a reduced prevalence of both clinical and radiological focal inflammatory disease activity. Older patients showed also increased CSF levels of lactate and that of the pro-inflammatory molecules monocyte chemoattractant protein 1 (MCP-1)/CCL2, macrophage inflammatory protein 1-alpha (MIP-1α)/CCL3, and interleukin (IL)-8. Finally, TMS evidenced a negative correlation between age and LTP-like plasticity. In newly diagnosed RR-MS, older age at onset is associated with reduced acute disease activity, increased oxidative stress, enhanced central inflammation, and altered synaptic plasticity. Independently of their age, patients with multiple sclerosis (MS) showing similar clinical, immunological, and neurophysiological characteristics may represent ideal candidates for early treatments effective against PIRA.

Stampanoni Bassi, M., Gilio, L., Iezzi, E., Moscatelli, A., Pekmezovic, T., Drulovic, J., et al. (2021). Age at disease onset associates with oxidative stress, neuroinflammation, and impaired synaptic plasticity in relapsing-remitting multiple sclerosis. FRONTIERS IN AGING NEUROSCIENCE, 13 [10.3389/fnagi.2021.694651].

Age at disease onset associates with oxidative stress, neuroinflammation, and impaired synaptic plasticity in relapsing-remitting multiple sclerosis

Moscatelli, Alessandro;Musella, Alessandra;Centonze, Diego;Buttari, Fabio
2021-09-10

Abstract

: Age at onset is the main risk factor for disease progression in patients with relapsing-remitting multiple sclerosis (RR-MS). In this cross-sectional study, we explored whether older age is associated with specific disease features involved in the progression independent of relapse activity (PIRA). In 266 patients with RR-MS, the associations between age at onset, clinical characteristics, cerebrospinal fluid (CSF) levels of lactate, and that of several inflammatory molecules were analyzed. The long-term potentiation (LTP)-like plasticity was studied using transcranial magnetic stimulation (TMS). Older age was associated with a reduced prevalence of both clinical and radiological focal inflammatory disease activity. Older patients showed also increased CSF levels of lactate and that of the pro-inflammatory molecules monocyte chemoattractant protein 1 (MCP-1)/CCL2, macrophage inflammatory protein 1-alpha (MIP-1α)/CCL3, and interleukin (IL)-8. Finally, TMS evidenced a negative correlation between age and LTP-like plasticity. In newly diagnosed RR-MS, older age at onset is associated with reduced acute disease activity, increased oxidative stress, enhanced central inflammation, and altered synaptic plasticity. Independently of their age, patients with multiple sclerosis (MS) showing similar clinical, immunological, and neurophysiological characteristics may represent ideal candidates for early treatments effective against PIRA.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26
eng
Con Impact Factor ISI
aging
neuroinflammation
oxidative stress
progression of disability independent of disease activity
relapsing remitting multiple sclerosis
synaptic plasticity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461180/pdf/fnagi-13-694651.pdf
Stampanoni Bassi, M., Gilio, L., Iezzi, E., Moscatelli, A., Pekmezovic, T., Drulovic, J., et al. (2021). Age at disease onset associates with oxidative stress, neuroinflammation, and impaired synaptic plasticity in relapsing-remitting multiple sclerosis. FRONTIERS IN AGING NEUROSCIENCE, 13 [10.3389/fnagi.2021.694651].
Stampanoni Bassi, M; Gilio, L; Iezzi, E; Moscatelli, A; Pekmezovic, T; Drulovic, J; Furlan, R; Finardi, A; Mandolesi, G; Musella, A; Galifi, G; Fantozzi, R; Bellantonio, P; Storto, M; Centonze, D; Buttari, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/282249
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