Synaptic transmission in the striatum is regulated by metabotropic glutamate (mGlu) receptors through pre- and postsynaptic mechanisms. We investigated the involvement of mGlu 1 and 5 receptors in the control of both excitatory and inhibitory transmission in the striatum. The mGlu 1 and 5 receptor agonist 3,5-DHPG failed to affect glutamate transmission, while it caused a biphasic effect on GABA transmission, characterized by early increase and late decrease in the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) recorded from striatal principal neurons. Both mGlu 1 and 5 receptors were involved in the early response to 3,5-DHPG, through membrane depolarization of striatal GABAergic interneurons and action potential generation. The 3,5-DHPG-mediated late depression of inhibitory inputs to striatal principal neurons was conversely secondary to mGlu 5 receptor activation and subsequent endocannabinoid release. In conclusion, we have identified an mGlu-dependent mechanism of GABA transmission regulation of potential relevance for physiological neuronal activity.

Centonze, D., Rossi, S., Prosperetti, C., Gasperi, V., De Chiara, V., Bari, M., et al. (2007). Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons. MOLECULAR AND CELLULAR NEUROSCIENCES, 35(2), 302-310 [10.1016/j.mcn.2007.03.005].

Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons

CENTONZE, DIEGO;GASPERI, VALERIA;BERNARDI, GIORGIO;MACCARRONE, MAURO
2007-06-01

Abstract

Synaptic transmission in the striatum is regulated by metabotropic glutamate (mGlu) receptors through pre- and postsynaptic mechanisms. We investigated the involvement of mGlu 1 and 5 receptors in the control of both excitatory and inhibitory transmission in the striatum. The mGlu 1 and 5 receptor agonist 3,5-DHPG failed to affect glutamate transmission, while it caused a biphasic effect on GABA transmission, characterized by early increase and late decrease in the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) recorded from striatal principal neurons. Both mGlu 1 and 5 receptors were involved in the early response to 3,5-DHPG, through membrane depolarization of striatal GABAergic interneurons and action potential generation. The 3,5-DHPG-mediated late depression of inhibitory inputs to striatal principal neurons was conversely secondary to mGlu 5 receptor activation and subsequent endocannabinoid release. In conclusion, we have identified an mGlu-dependent mechanism of GABA transmission regulation of potential relevance for physiological neuronal activity.
giu-2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
Settore BIO/10 - BIOCHIMICA
English
Con Impact Factor ISI
Corpus Striatum; Time Factors; Chromones; Receptors, Metabotropic Glutamate; Endocannabinoids; Methoxyhydroxyphenylglycol; Animals; Interneurons; Neural Inhibition; Tetrodotoxin; Action Potentials; Excitatory Amino Acid Antagonists; Mice; Excitatory Amino Acid Agonists; Mice, Inbred C57BL; gamma-Aminobutyric Acid; Synaptic Transmission; Drug Interactions
Centonze, D., Rossi, S., Prosperetti, C., Gasperi, V., De Chiara, V., Bari, M., et al. (2007). Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons. MOLECULAR AND CELLULAR NEUROSCIENCES, 35(2), 302-310 [10.1016/j.mcn.2007.03.005].
Centonze, D; Rossi, S; Prosperetti, C; Gasperi, V; De Chiara, V; Bari, M; Tscherter, A; Febbraro, F; Bernardi, G; Maccarrone, M
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/28090
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