Breast cancer is the second leading cause of cancer-related deaths among women, largely due to the progression of a significant fraction of primary tumours to the metastatic stage. Here, we show that zinc-finger protein 750 (ZNF750) opposes the migration and invasion of breast cancer cells by repressing a prometastatic transcriptional programme, which includes genes involved in focal adhesion and extracellular matrix interactions, such as LAMB3 and CTNNAL1. Mechanistically, ZNF750 recruits the epigenetic modifiers KDM1A and HDAC1 to the promoter regions of LAMB3 and CTNNAL1, influencing histone marks and transactivating these genomic sites. Gene expression analysis in cancer patient datasets indicated that ZNF750 and its targets were negative prognostic factors in breast cancer. Together, our findings shed light on the molecular mechanism by which ZNF750 regulates cell migration and invasion, suggesting a role in breast cancer metastasis.

Cassandri, M., Butera, A., Amelio, I., Lena, A.m., Montanaro, M., Mauriello, A., et al. (2020). ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. ONCOGENE, 39(22), 4331-4343 [10.1038/s41388-020-1277-5].

ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes

Cassandri, Matteo;Amelio, Ivano;Lena, Anna Maria;Mauriello, Alessandro;Anemona, Lucia;Candi, Eleonora;Agostini, Massimiliano
;
Melino, Gerry
2020

Abstract

Breast cancer is the second leading cause of cancer-related deaths among women, largely due to the progression of a significant fraction of primary tumours to the metastatic stage. Here, we show that zinc-finger protein 750 (ZNF750) opposes the migration and invasion of breast cancer cells by repressing a prometastatic transcriptional programme, which includes genes involved in focal adhesion and extracellular matrix interactions, such as LAMB3 and CTNNAL1. Mechanistically, ZNF750 recruits the epigenetic modifiers KDM1A and HDAC1 to the promoter regions of LAMB3 and CTNNAL1, influencing histone marks and transactivating these genomic sites. Gene expression analysis in cancer patient datasets indicated that ZNF750 and its targets were negative prognostic factors in breast cancer. Together, our findings shed light on the molecular mechanism by which ZNF750 regulates cell migration and invasion, suggesting a role in breast cancer metastasis.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/11
English
Breast Neoplasms
Cell Adhesion Molecules
Cell Movement
Neoplasm Metastasis
Cassandri, M., Butera, A., Amelio, I., Lena, A.m., Montanaro, M., Mauriello, A., et al. (2020). ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. ONCOGENE, 39(22), 4331-4343 [10.1038/s41388-020-1277-5].
Cassandri, M; Butera, A; Amelio, I; Lena, Am; Montanaro, M; Mauriello, A; Anemona, L; Candi, E; Knight, Ra; Agostini, M; Melino, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/280611
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