Volatolomics is gaining consideration as a viable approach to diagnose several diseases, and it also shows promising results to discriminate COVID-19 patients via breath analysis. This paper extends the study of the relationship between volatile compounds (VOCs) and COVID-19 to blood serum. Blood samples were collected from subjects recruited at the emergency department of a large public hospital. The VOCs were analyzed with a gas chromatography mass spectrometer (GC/MS). GC/MS data show that in more than 100 different VOCs, the pattern of abundances of 17 compounds identifies COVID-19 from non-COVID with an accuracy of 89% (sensitivity 94% and specificity 83%). GC/MS analysis was complemented by an array of gas sensors whose data achieved an accuracy of 89% (sensitivity 94% and specificity 80%).

Mougang, Y.k., Di Zazzo, L., Minieri, M., Capuano, R., Catini, A., Legramante, J.m., et al. (2021). Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19. ISCIENCE, 24(8), 102851 [10.1016/j.isci.2021.102851].

Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19

Minieri, Marilena;Capuano, Rosamaria;Catini, Alexandro;Legramante, Jacopo Maria;Paolesse, Roberto;Bernardini, Sergio;Di Natale, Corrado
2021-08-20

Abstract

Volatolomics is gaining consideration as a viable approach to diagnose several diseases, and it also shows promising results to discriminate COVID-19 patients via breath analysis. This paper extends the study of the relationship between volatile compounds (VOCs) and COVID-19 to blood serum. Blood samples were collected from subjects recruited at the emergency department of a large public hospital. The VOCs were analyzed with a gas chromatography mass spectrometer (GC/MS). GC/MS data show that in more than 100 different VOCs, the pattern of abundances of 17 compounds identifies COVID-19 from non-COVID with an accuracy of 89% (sensitivity 94% and specificity 83%). GC/MS analysis was complemented by an array of gas sensors whose data achieved an accuracy of 89% (sensitivity 94% and specificity 80%).
20-ago-2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - MEDICINA INTERNA
English
Biotechnology
Diagnostics
Health sciences
Medical biotechnology
Mougang, Y.k., Di Zazzo, L., Minieri, M., Capuano, R., Catini, A., Legramante, J.m., et al. (2021). Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19. ISCIENCE, 24(8), 102851 [10.1016/j.isci.2021.102851].
Mougang, Yk; Di Zazzo, L; Minieri, M; Capuano, R; Catini, A; Legramante, Jm; Paolesse, R; Bernardini, S; Di Natale, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/279285
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