The interest of inner ear research towards the cochlear simulation is due to the lack of imaging techniques for human noninvasive investigation. Unfortunately, in case of Sensorineural Hearing Loss (SHL), the majority of the models developed in the literature do not take into consideration all the complex audiological phenomena occurring in the Organ of Corti. In this paper we show that a realistic analysis of recruitment and hyperacusis can be effectively reproduced by nonlinear modeling. The latter fact is in contrast to the classical assumption that an impaired ear with a moderate SHL can be effectively described by a passive linear model. In order to deal with the active role performed by the Outer Hair Cells (OHC), recent models based on integro-differential equations were introduced in the literature. However, the discretization and the computational methods present some issues. In this work we suggest the utilization of a variable-step-variable order package to advance in time in order to preserve the character of the continuous solution. Moreover, we illustrate that, in case of SHL, the fixed-point approach for the linear algebraic system generated by the discretization can be inappropriate. Since preliminary experiences show that the matrices involved in the model present clustered eigenvalues, we propose Krylov methods. Numerical tests are included in order to confirm the effectiveness of the proposal. (C) 2009 IMACS. Published by Elsevier B.V. All rights reserved.

Bertaccini, D., & Fanelli, S. (2009). Computational and conditioning issues of a discrete model for cochlear sensorineural hypoacusia. APPLIED NUMERICAL MATHEMATICS, 59(8), 1989-2001 [10.1016/j.apnum.2009.03.001].

Computational and conditioning issues of a discrete model for cochlear sensorineural hypoacusia

BERTACCINI, DANIELE;FANELLI, STEFANO
2009

Abstract

The interest of inner ear research towards the cochlear simulation is due to the lack of imaging techniques for human noninvasive investigation. Unfortunately, in case of Sensorineural Hearing Loss (SHL), the majority of the models developed in the literature do not take into consideration all the complex audiological phenomena occurring in the Organ of Corti. In this paper we show that a realistic analysis of recruitment and hyperacusis can be effectively reproduced by nonlinear modeling. The latter fact is in contrast to the classical assumption that an impaired ear with a moderate SHL can be effectively described by a passive linear model. In order to deal with the active role performed by the Outer Hair Cells (OHC), recent models based on integro-differential equations were introduced in the literature. However, the discretization and the computational methods present some issues. In this work we suggest the utilization of a variable-step-variable order package to advance in time in order to preserve the character of the continuous solution. Moreover, we illustrate that, in case of SHL, the fixed-point approach for the linear algebraic system generated by the discretization can be inappropriate. Since preliminary experiences show that the matrices involved in the model present clustered eigenvalues, we propose Krylov methods. Numerical tests are included in order to confirm the effectiveness of the proposal. (C) 2009 IMACS. Published by Elsevier B.V. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MAT/08 - Analisi Numerica
English
Con Impact Factor ISI
Cochlear modeling; Conditioning; Integrodifferential models; Iterative methods
Bertaccini, D., & Fanelli, S. (2009). Computational and conditioning issues of a discrete model for cochlear sensorineural hypoacusia. APPLIED NUMERICAL MATHEMATICS, 59(8), 1989-2001 [10.1016/j.apnum.2009.03.001].
Bertaccini, D; Fanelli, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/27793
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