DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. the epigenetic component is strongly involved in aging‐bone diseases, such as osteoporosis and osteoarthritis. both are complex multi-factorial late‐onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. in recent years, new findings on the role of DNA methylation in the pathogenesis of aging‐bone diseases have emerged. the aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.

Visconti, V.v., Cariati, I., Fittipaldi, S., Iundusi, R., Gasbarra, E., Tarantino, U., et al. (2021). DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(8), 4244 [10.3390/ijms22084244].

DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review

Cariati, Ida;Iundusi, Riccardo;Gasbarra, Elena;Tarantino, Umberto;Botta, Annalisa
2021-03-31

Abstract

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. the epigenetic component is strongly involved in aging‐bone diseases, such as osteoporosis and osteoarthritis. both are complex multi-factorial late‐onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. in recent years, new findings on the role of DNA methylation in the pathogenesis of aging‐bone diseases have emerged. the aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.
31-mar-2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03 - GENETICA MEDICA
Settore M-EDF/01
Settore MEDF-01/A - Metodi e didattiche delle attività motorie
English
Visconti, V.v., Cariati, I., Fittipaldi, S., Iundusi, R., Gasbarra, E., Tarantino, U., et al. (2021). DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(8), 4244 [10.3390/ijms22084244].
Visconti, Vv; Cariati, I; Fittipaldi, S; Iundusi, R; Gasbarra, E; Tarantino, U; Botta, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/275408
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