Treatment of olive vegetation waste with tyrosinase immobilized on multiwalled carbon nanotubes increased the antioxidant activity as a consequence of the conversion of phenols to corresponding catechol derivatives, as evaluated by DPPH, Comet assay, and micronucleus analyses. During this transformation, 4-hydroxyphenethyl alcohol (tyrosol) was quantitatively converted to bioactive 3,4-dihydroxyphenethyl alcohol (hydroxytyrosol). The hydroxytyrosol-enriched olive vegetation waste also promoted autophagy and inhibited the inflammatory response in human THP-1 monocytes.

Meschini, R., D'Eliseo, D., Filippi, S., Bertini, L., Bizzarri, B.m., Botta, L., et al. (2018). Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(46), 12274-12284 [10.1021/acs.jafc.8b03630].

Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes

Botta L.;
2018-01-01

Abstract

Treatment of olive vegetation waste with tyrosinase immobilized on multiwalled carbon nanotubes increased the antioxidant activity as a consequence of the conversion of phenols to corresponding catechol derivatives, as evaluated by DPPH, Comet assay, and micronucleus analyses. During this transformation, 4-hydroxyphenethyl alcohol (tyrosol) was quantitatively converted to bioactive 3,4-dihydroxyphenethyl alcohol (hydroxytyrosol). The hydroxytyrosol-enriched olive vegetation waste also promoted autophagy and inhibited the inflammatory response in human THP-1 monocytes.
2018
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/06 - CHIMICA ORGANICA
English
antioxidant activity; autophagy; cytokines; hydroxytyrosol; inflammation; olive vegetation waste; tyrosinase bioconversion; Antioxidants; Autophagy; Biocatalysis; Cell Line; Humans; Monocytes; Monophenol Monooxygenase; Olea; Phenylethyl Alcohol; Plant Extracts; Waste Products
Meschini, R., D'Eliseo, D., Filippi, S., Bertini, L., Bizzarri, B.m., Botta, L., et al. (2018). Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(46), 12274-12284 [10.1021/acs.jafc.8b03630].
Meschini, R; D'Eliseo, D; Filippi, S; Bertini, L; Bizzarri, Bm; Botta, L; Saladino, R; Velotti, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/273585
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