Alzheimer's disease (AD) is considered a clinical and biological continuum identified via cerebrospinal fluid (CSF) or imaging biomarkers. Chronic hypoperfusion is held as one of the main features of Alzheimer's disease, as part of the processes causing neuronal degeneration. The mechanism responsible for such condition is still debated, though recently a direct connection with amyloid peptides has been shown. Here we aimed at investigating whether measures of hypoperfusion change along the AD continuum.

Diomedi, M., Rocco, A., Bonomi, C.g., Mascolo, A.p., De Lucia, V., Marrama, F., et al. (2021). Hemodynamic impairment along the Alzheimer's Disease continuum. EUROPEAN JOURNAL OF NEUROLOGY [10.1111/ene.14834].

Hemodynamic impairment along the Alzheimer's Disease continuum

Diomedi, Marina;
2021-03-23

Abstract

Alzheimer's disease (AD) is considered a clinical and biological continuum identified via cerebrospinal fluid (CSF) or imaging biomarkers. Chronic hypoperfusion is held as one of the main features of Alzheimer's disease, as part of the processes causing neuronal degeneration. The mechanism responsible for such condition is still debated, though recently a direct connection with amyloid peptides has been shown. Here we aimed at investigating whether measures of hypoperfusion change along the AD continuum.
23-mar-2021
Online ahead of print
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Aβ42
BHI
CSF
epsilon genotype
vascular reactivity
Alzheimer’s disease
Diomedi, M., Rocco, A., Bonomi, C.g., Mascolo, A.p., De Lucia, V., Marrama, F., et al. (2021). Hemodynamic impairment along the Alzheimer's Disease continuum. EUROPEAN JOURNAL OF NEUROLOGY [10.1111/ene.14834].
Diomedi, M; Rocco, A; Bonomi, Cg; Mascolo, Ap; De Lucia, V; Marrama, F; Sallustio, F; Koch, G; Martorana, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/272030
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