One of the earliest neurochemical alterations observed in both Huntington's disease (HD) patients and HD animal models is the dysregulation of the endocannabinoid system, an alteration that precedes the development of identifiable striatal neuropathology. How this alteration impacts striatal synaptic transmission is unknown.

Centonze, D., Rossi, S., Prosperetti, C., Tscherter, A., Bernardi, G., Maccarrone, M., et al. (2005). Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice. BIOLOGICAL PSYCHIATRY, 57(12), 1583-1589 [10.1016/j.biopsych.2005.03.008].

Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice

CENTONZE, DIEGO;BERNARDI, GIORGIO;MACCARRONE, MAURO;CALABRESI, PAOLO
2005-06-15

Abstract

One of the earliest neurochemical alterations observed in both Huntington's disease (HD) patients and HD animal models is the dysregulation of the endocannabinoid system, an alteration that precedes the development of identifiable striatal neuropathology. How this alteration impacts striatal synaptic transmission is unknown.
15-giu-2005
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Corpus Striatum; Time Factors; Receptors, Cannabinoid; Animals; Huntington Disease; Electric Stimulation; Patch-Clamp Techniques; Mice, Transgenic; Neural Inhibition; Animals, Newborn; Membrane Potentials; Excitatory Amino Acid Antagonists; Neurons; Mice; Pyrazoles; Piperidines; gamma-Aminobutyric Acid; Synaptic Transmission; Drug Interactions
Centonze, D., Rossi, S., Prosperetti, C., Tscherter, A., Bernardi, G., Maccarrone, M., et al. (2005). Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice. BIOLOGICAL PSYCHIATRY, 57(12), 1583-1589 [10.1016/j.biopsych.2005.03.008].
Centonze, D; Rossi, S; Prosperetti, C; Tscherter, A; Bernardi, G; Maccarrone, M; Calabresi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/27175
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