Michael-type addition reactions offer the possibility to obtain in situ formation of polymeric hydrogels in the absence of a radical mechanism for the networking process. We explored such a synthetic route for obtaining a poly(vinyl alcohol) (PVA)-based hydrogel as a potential biomaterial for applications in vitro-retinal replacement surgery. The presence of radicals in the reaction medium can represent a risk for in situ surgical treatment. To circumvent this problem we have applied nucleophilic addition to ad hoc modified PVA macromers. The gel formation has been studied with respect to the timing required in this surgery and in terms of the structural characteristics of the obtained network.

Tortora, M., Cavalieri, F., Chiessi, E., Paradossi, G. (2007). Michael-type addition reactions for the in situ formation of poly(vinyl alcohol)-based hydrogels. BIOMACROMOLECULES, 8(1), 209-214 [10.1021/bm0607269].

Michael-type addition reactions for the in situ formation of poly(vinyl alcohol)-based hydrogels

CAVALIERI, FRANCESCA;
2007-01-01

Abstract

Michael-type addition reactions offer the possibility to obtain in situ formation of polymeric hydrogels in the absence of a radical mechanism for the networking process. We explored such a synthetic route for obtaining a poly(vinyl alcohol) (PVA)-based hydrogel as a potential biomaterial for applications in vitro-retinal replacement surgery. The presence of radicals in the reaction medium can represent a risk for in situ surgical treatment. To circumvent this problem we have applied nucleophilic addition to ad hoc modified PVA macromers. The gel formation has been studied with respect to the timing required in this surgery and in terms of the structural characteristics of the obtained network.
2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/02 - CHIMICA FISICA
English
Con Impact Factor ISI
Addition reactions; Biomaterials; Hydrogels; Surgery; Michael-type addition reactions; Nucleophilic addition; Vitro-retinal replacement surgery; Polyvinyl alcohols; biomaterial; polyvinyl alcohol; radical; article; artificial organ; chemical reaction; controlled study; hydrogel; Michael addition; priority journal; retina; surgical risk; synthesis; vitreous body; Alcohols; Biochemistry; Biocompatible Materials; Free Radicals; Hydrogels; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Magnetic Resonance Spectroscopy; Materials Testing; Models, Chemical; Polymers; Polyvinyl Alcohol; Time Factors
Tortora, M., Cavalieri, F., Chiessi, E., Paradossi, G. (2007). Michael-type addition reactions for the in situ formation of poly(vinyl alcohol)-based hydrogels. BIOMACROMOLECULES, 8(1), 209-214 [10.1021/bm0607269].
Tortora, M; Cavalieri, F; Chiessi, E; Paradossi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/27134
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