Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. Reduction in FLASH expression by short hairpin RNA results in disruption of the normal architecture of the Cajal body and relocalization of its components. Because the function of FLASH in the apoptosis receptor signaling pathway has been strongly questioned, we have now identified a clear function for this protein.

Barcaroli D., D.D. (2006). FLASH is an essential component of Cajal bodies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(40), 14802-14807 [10.1073/pnas.0604225103].

FLASH is an essential component of Cajal bodies

BONGIORNO BORBONE, LUCILLA;RANALLI, MARCO;MELINO, GENNARO;DE LAURENZI, VINCENZO
2006

Abstract

Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. Reduction in FLASH expression by short hairpin RNA results in disruption of the normal architecture of the Cajal body and relocalization of its components. Because the function of FLASH in the apoptosis receptor signaling pathway has been strongly questioned, we have now identified a clear function for this protein.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/11
English
Con Impact Factor ISI
Coiled bodies; Nuclear organelles
Barcaroli D., D.D. (2006). FLASH is an essential component of Cajal bodies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(40), 14802-14807 [10.1073/pnas.0604225103].
Barcaroli, D; Dinsdale, D; Neale, Mh; BONGIORNO BORBONE, L; Ranalli, M; Munarriz, E; Sayan, Ae; Mcwilliam, Jm; Smith, Tm; Fava, E; Knight, Ra; Melino, G; DE LAURENZI, V
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/27089
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