The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this review, we focus our attention on the metabolic aspects of some natural compounds (methylxantines, retinoids and flavonoids) responsible of their antitumor effects exerted through the induction of TG activity in cancer cells.

Lentini, A., Provenzano, B., Tabolacci, C., Beninati, S. (2009). Protein–polyamine conjugates by transglutaminase 2 as potential markers for antineoplastic screening of natural compounds. AMINO ACIDS, 36(4), 701-708 [10.1007/s00726-008-0157-z].

Protein–polyamine conjugates by transglutaminase 2 as potential markers for antineoplastic screening of natural compounds

LENTINI, ALESSANDRO;PROVENZANO, BRUNO;BENINATI, SIMONE
2009-01-01

Abstract

The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this review, we focus our attention on the metabolic aspects of some natural compounds (methylxantines, retinoids and flavonoids) responsible of their antitumor effects exerted through the induction of TG activity in cancer cells.
2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Lentini, A., Provenzano, B., Tabolacci, C., Beninati, S. (2009). Protein–polyamine conjugates by transglutaminase 2 as potential markers for antineoplastic screening of natural compounds. AMINO ACIDS, 36(4), 701-708 [10.1007/s00726-008-0157-z].
Lentini, A; Provenzano, B; Tabolacci, C; Beninati, S
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/26878
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 19
social impact