The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in nearly all human tissues. In the conjunctiva and cornea, the ECS is believed to play a pivotal role in the modulation of the local inflammatory state as well as in the regulation of tissue repair and fibrosis, neo-angiogenesis and pain perception. This review aims to summarize all the available data on ECS expression and its function in ocular surface structures to provide a specific insight concerning its modulation in dry eye disease, and to propose directions for future research.

Aiello, F., Gallo Afflitto, G., Li, J.o., Martucci, A., Cesareo, M., Nucci, C. (2020). CannabinEYEds: the endocannabinoid system as a regulator of the ocular surface nociception, inflammatory response, neovascularization and wound healing. JOURNAL OF CLINICAL MEDICINE, 9(12) [10.3390/jcm9124036].

CannabinEYEds: the endocannabinoid system as a regulator of the ocular surface nociception, inflammatory response, neovascularization and wound healing

Aiello, Francesco;Martucci, Alessio;Cesareo, Massimo;Nucci, Carlo
2020-12-14

Abstract

The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in nearly all human tissues. In the conjunctiva and cornea, the ECS is believed to play a pivotal role in the modulation of the local inflammatory state as well as in the regulation of tissue repair and fibrosis, neo-angiogenesis and pain perception. This review aims to summarize all the available data on ECS expression and its function in ocular surface structures to provide a specific insight concerning its modulation in dry eye disease, and to propose directions for future research.
14-dic-2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/30 - MALATTIE APPARATO VISIVO
English
CB1-receptor; CB2-receptor; ECS; PPAR; TRPV1; conjunctiva; cornea; dry eye; endocannabinoid system; ocular surface
Aiello, F., Gallo Afflitto, G., Li, J.o., Martucci, A., Cesareo, M., Nucci, C. (2020). CannabinEYEds: the endocannabinoid system as a regulator of the ocular surface nociception, inflammatory response, neovascularization and wound healing. JOURNAL OF CLINICAL MEDICINE, 9(12) [10.3390/jcm9124036].
Aiello, F; Gallo Afflitto, G; Li, Jo; Martucci, A; Cesareo, M; Nucci, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/267325
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