Poly(N-isopropylacrylamide) (PNIPAM) hydrogel microparticles with different core-shell morphologies have been designed, while maintaining an unvaried chemical composition: a morphology with (i) an un-crosslinked core with a crosslinked shell of PNIPAM chains and (ii) PNIPAM chains crosslinked to form the core with a shell consisting of tethered un-crosslinked PNIPAM chains to the core. Both morphologies with two different degrees of crosslinking have been assessed by confocal microscopy and tested with respect to their temperature responsivity and deformation by applying an osmotic stress. The thermal and mechanical behavior of these architectures have been framed within a Flory-Rehner modified model in order to describe the microgel volume shrinking occurring as response to a temperature increase or an osmotic perturbation. This study provides a background for assessing to what extent the mechanical features of the microgel particle surface affect the interactions occurring at the interface of a microgel particle with a cell, in addition to the already know ligand/receptor interaction. These results have direct implications in triggering a limited phagocytosis of microdevices designed as injectable drug delivery systems.

Ruscito, A., Chiessi, E., Toumia, Y., Oddo, L., Domenici, F., & Paradossi, G. (2020). Microgel particles with distinct morphologies and common chemical compositions: a unified descrip-tion of the responsivity to temperature and osmotic stress. GELS, 6(4), 1-19 [10.3390/gels6040034].

Microgel particles with distinct morphologies and common chemical compositions: a unified descrip-tion of the responsivity to temperature and osmotic stress

Chiessi E.;Toumia Y.;Oddo L.;Domenici F.;Paradossi G.
2020

Abstract

Poly(N-isopropylacrylamide) (PNIPAM) hydrogel microparticles with different core-shell morphologies have been designed, while maintaining an unvaried chemical composition: a morphology with (i) an un-crosslinked core with a crosslinked shell of PNIPAM chains and (ii) PNIPAM chains crosslinked to form the core with a shell consisting of tethered un-crosslinked PNIPAM chains to the core. Both morphologies with two different degrees of crosslinking have been assessed by confocal microscopy and tested with respect to their temperature responsivity and deformation by applying an osmotic stress. The thermal and mechanical behavior of these architectures have been framed within a Flory-Rehner modified model in order to describe the microgel volume shrinking occurring as response to a temperature increase or an osmotic perturbation. This study provides a background for assessing to what extent the mechanical features of the microgel particle surface affect the interactions occurring at the interface of a microgel particle with a cell, in addition to the already know ligand/receptor interaction. These results have direct implications in triggering a limited phagocytosis of microdevices designed as injectable drug delivery systems.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/02
English
Flory–Rehner; PNIPAM; crosslinks; drug delivery systems; hydrogels; osmotic pressure; swelling
Ruscito, A., Chiessi, E., Toumia, Y., Oddo, L., Domenici, F., & Paradossi, G. (2020). Microgel particles with distinct morphologies and common chemical compositions: a unified descrip-tion of the responsivity to temperature and osmotic stress. GELS, 6(4), 1-19 [10.3390/gels6040034].
Ruscito, A; Chiessi, E; Toumia, Y; Oddo, L; Domenici, F; Paradossi, G
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
gels-06-00034-v3.pdf

accesso aperto

Descrizione: Aticolo principale
Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 2.54 MB
Formato Adobe PDF
2.54 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/266996
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 3
social impact