Micromolar concentrations of the proangiogenic metabolite deoxyribose-1-phosphate (dRP) were detected in platelet supernatants by mass spectrometry. In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis.

Pula, G., Garonna, E., Dunn, W.b., Hirano, M., Pizzorno, G., Campanella, M., et al. (2010). Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate. ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, 30(12), 2631-2638 [10.1161/ATVBAHA.110.215855].

Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate

Campanella, Michelangelo
;
2010-12-01

Abstract

Micromolar concentrations of the proangiogenic metabolite deoxyribose-1-phosphate (dRP) were detected in platelet supernatants by mass spectrometry. In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis.
dic-2010
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Animals
Blood Platelets
Cells, Cultured
Chick Embryo
Chorioallantoic Membrane
Endothelial Cells
Enzyme Inhibitors
Gas Chromatography-Mass Spectrometry
Gene Silencing
Humans
Integrin alphaV
Integrin alphaVbeta3
Integrin beta3
Reactive Oxygen Species
Ribosemonophosphates
Thrombin
Thymidine Phosphorylase
Time Factors
Uridine Phosphorylase
Cell Movement
Neovascularization, Physiologic
Paracrine Communication
Pula, G., Garonna, E., Dunn, W.b., Hirano, M., Pizzorno, G., Campanella, M., et al. (2010). Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate. ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, 30(12), 2631-2638 [10.1161/ATVBAHA.110.215855].
Pula, G; Garonna, E; Dunn, Wb; Hirano, M; Pizzorno, G; Campanella, M; Schwartz, El; El Kouni, Mh; Wheeler-Jones, Cpd
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/265733
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 16
social impact