AIM: Aspergillus fumigatus is the most common opportunistic fungal pathogen and causes invasive pulmonary aspergillosis (IPA), with high mortality among immunosuppressed patients. Fungistatic activity of all-trans retinoic acid (ATRA) has been recently described in vitroWe evaluated the efficacy of ATRA in vivo and its potential synergistic interaction with other antifungal drugs.

Campione, E., Gaziano, R., Doldo, E., Marino, D., Falconi, M., Iacovelli, F., et al. (2021). Antifungal effect of all-trans retinoic acid against aspergillus fumigatus in vitro and in a pulmonary aspergillosis in vivo model. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 65(3) [10.1128/AAC.01874-20].

Antifungal effect of all-trans retinoic acid against aspergillus fumigatus in vitro and in a pulmonary aspergillosis in vivo model

Campione, Elena;Gaziano, Roberta;Doldo, Elena;Falconi, Mattia;Iacovelli, Federico;Bianchi, Luca;Di Francesco, Paolo;Del Principe, Ilaria;Pistoia, Enrico Salvatore;Orlandi, Augusto
2021-01-01

Abstract

AIM: Aspergillus fumigatus is the most common opportunistic fungal pathogen and causes invasive pulmonary aspergillosis (IPA), with high mortality among immunosuppressed patients. Fungistatic activity of all-trans retinoic acid (ATRA) has been recently described in vitroWe evaluated the efficacy of ATRA in vivo and its potential synergistic interaction with other antifungal drugs.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/35 - MALATTIE CUTANEE E VENEREE
English
Campione, E., Gaziano, R., Doldo, E., Marino, D., Falconi, M., Iacovelli, F., et al. (2021). Antifungal effect of all-trans retinoic acid against aspergillus fumigatus in vitro and in a pulmonary aspergillosis in vivo model. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 65(3) [10.1128/AAC.01874-20].
Campione, E; Gaziano, R; Doldo, E; Marino, D; Falconi, M; Iacovelli, F; Tagliaferri, D; Pacello, L; Bianchi, L; Lanna, C; Aurisicchio, L; Centofanti, F; Di Francesco, P; Del Principe, I; Del Bufalo, F; Locatelli, F; Pistoia, Es; Marra, E; Orlandi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/265367
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