The increasing interest for microfluidic devices in medicine and biology has opened the way to new time-lapse microscopy era where the amount of images and their acquisition time will become crucial. In this optic, new data analysis algorithms have to be developed in order to extract novel features of cell behavior and cell-cell interactions. In this brief article, we emphasize the potential strength of a new paradigm arising in the integration of microfluidic devices (i.e., organ on chip), time-lapse microscopy analysis, and machine learning approaches. Some snapshots of previous case studies in the context of immunotherapy are included as proof of concepts of the proposed strategies while a visionary description concludes the work foreseeing future research and applicative scenarios.

Mencattini, A., Mattei, F., Schiavoni, G., Gerardino, A., Businaro, L., Di Natale, C., et al. (2019). From petri dishes to organ on chip platform: The increasing importance of machine learning and image analysis. FRONTIERS IN PHARMACOLOGY, 10, 100 [10.3389/fphar.2019.00100].

From petri dishes to organ on chip platform: The increasing importance of machine learning and image analysis

Mencattini A.;Di Natale C.;Martinelli E.
2019-01-01

Abstract

The increasing interest for microfluidic devices in medicine and biology has opened the way to new time-lapse microscopy era where the amount of images and their acquisition time will become crucial. In this optic, new data analysis algorithms have to be developed in order to extract novel features of cell behavior and cell-cell interactions. In this brief article, we emphasize the potential strength of a new paradigm arising in the integration of microfluidic devices (i.e., organ on chip), time-lapse microscopy analysis, and machine learning approaches. Some snapshots of previous case studies in the context of immunotherapy are included as proof of concepts of the proposed strategies while a visionary description concludes the work foreseeing future research and applicative scenarios.
2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore ING-INF/07 - MISURE ELETTRICHE ED ELETTRONICHE
English
Cell interaction analysis
Image analysis
Machine learning
Organ on chip
Time-lapse microscopy
Mencattini, A., Mattei, F., Schiavoni, G., Gerardino, A., Businaro, L., Di Natale, C., et al. (2019). From petri dishes to organ on chip platform: The increasing importance of machine learning and image analysis. FRONTIERS IN PHARMACOLOGY, 10, 100 [10.3389/fphar.2019.00100].
Mencattini, A; Mattei, F; Schiavoni, G; Gerardino, A; Businaro, L; Di Natale, C; Martinelli, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/265016
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