In the recent years the rapid scientific innovation in the evaluation of the individual's genome have allowed the identification of variants associated with the onset, treatment and prognosis of various pathologies including cancer, and with a potential impact in the assessment of therapy responses. Despite the analysis and interpretation of genomic information is considered incomplete, in many cases the identification of specific genomic profile has allowed the stratification of subgroups of patients characterized by a better response to drug therapies. Individual genome analysis has changed profoundly the diagnostic and therapeutic approach of breast cancer in the last 15 years by identifying selective molecular lesions that drive the development of neoplasms, showing that each tumor has its own genomic signature, with some specific features and some features common to several sub-types. Several personalized therapies have been (and still are being) developed showing a remarkable efficacy in the treatment of breast cancer.

Biancolella, M., Testa, B., Baghernajad Salehi, L., D'Apice, M.r., Novelli, G. (2021). Genetics and genomics of breast cancer: update and translational perspectives. SEMINARS IN CANCER BIOLOGY, 72, 27-35 [10.1016/j.semcancer.2020.03.013].

Genetics and genomics of breast cancer: update and translational perspectives

Biancolella M.;Testa B.;Novelli G.
2021-01-01

Abstract

In the recent years the rapid scientific innovation in the evaluation of the individual's genome have allowed the identification of variants associated with the onset, treatment and prognosis of various pathologies including cancer, and with a potential impact in the assessment of therapy responses. Despite the analysis and interpretation of genomic information is considered incomplete, in many cases the identification of specific genomic profile has allowed the stratification of subgroups of patients characterized by a better response to drug therapies. Individual genome analysis has changed profoundly the diagnostic and therapeutic approach of breast cancer in the last 15 years by identifying selective molecular lesions that drive the development of neoplasms, showing that each tumor has its own genomic signature, with some specific features and some features common to several sub-types. Several personalized therapies have been (and still are being) developed showing a remarkable efficacy in the treatment of breast cancer.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03 - GENETICA MEDICA
English
mutation analysis; target therapy; breast cancer; genomics; precision medicine
Biancolella, M., Testa, B., Baghernajad Salehi, L., D'Apice, M.r., Novelli, G. (2021). Genetics and genomics of breast cancer: update and translational perspectives. SEMINARS IN CANCER BIOLOGY, 72, 27-35 [10.1016/j.semcancer.2020.03.013].
Biancolella, M; Testa, B; Baghernajad Salehi, L; D'Apice, Mr; Novelli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/264365
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