The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in the formation of these calcium deposits, as well as the prognostic significance of their presence in human tissues, have not been completely elucidated. Therefore, a better characterization of the biological process related to the formation of calcifications in different tissues and organs, as well as the understanding of the prognostic significance of the presence of these calcium deposits into human tissues could significantly improve the management of patients characterized by microcalcifications associated lesions. Starting from these considerations, this narrative review highlights the most recent histopathological and molecular data concerning the formation of calcifications in breast, thyroid, lung, and ovarian diseases. Evidence reported here could deeply change the current point of view concerning the role of ectopic calcifications in the progression of human diseases and also in the patients' management. In fact, the presence of calcifications can suggest an unfavorable prognosis due to dysregulation of normal tissues homeostasis.

Bonfiglio, R., Granaglia, A., Giocondo, R., Scimeca, M., Bonanno, E. (2021). Molecular aspects and prognostic significance of microcalcifications in human pathology: a narrative review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(1) [10.3390/ijms22010120].

Molecular aspects and prognostic significance of microcalcifications in human pathology: a narrative review

Bonfiglio, Rita;Scimeca, Manuel;Bonanno, Elena
2021-01-01

Abstract

The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in the formation of these calcium deposits, as well as the prognostic significance of their presence in human tissues, have not been completely elucidated. Therefore, a better characterization of the biological process related to the formation of calcifications in different tissues and organs, as well as the understanding of the prognostic significance of the presence of these calcium deposits into human tissues could significantly improve the management of patients characterized by microcalcifications associated lesions. Starting from these considerations, this narrative review highlights the most recent histopathological and molecular data concerning the formation of calcifications in breast, thyroid, lung, and ovarian diseases. Evidence reported here could deeply change the current point of view concerning the role of ectopic calcifications in the progression of human diseases and also in the patients' management. In fact, the presence of calcifications can suggest an unfavorable prognosis due to dysregulation of normal tissues homeostasis.
2021
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
Settore MEDS-04/A - Anatomia patologica
English
EMT
breast cancer
ectopic calcifications
lung
microcalcifications
osteoblast-like cells
ovary
thyroid
Bonfiglio, R., Granaglia, A., Giocondo, R., Scimeca, M., Bonanno, E. (2021). Molecular aspects and prognostic significance of microcalcifications in human pathology: a narrative review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(1) [10.3390/ijms22010120].
Bonfiglio, R; Granaglia, A; Giocondo, R; Scimeca, M; Bonanno, E
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
ijms-22-00120.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Licenza: Copyright dell'editore
Dimensione 1.32 MB
Formato Adobe PDF
1.32 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/264151
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 8
social impact