Macrophage migration inhibitory factor (MIF), a multifunctional proinflammatory cytokine, has been recently involved in many aspects of reproduction including pregnancy. However, no evidence is available on the role of MIF in gestational tissues nor on factors regulating MIF production. This study, conducted on explants of human fetal membranes at term gestation, has been undertaken to investigate whether: (1) MIF is produced by fetal membranes; (2) nitric oxide (NO) can regulate local MIF production; and (3) MIF, in turn, can influence NO release in these tissues.
Zicari, A., Ticconi, C., Ietta, F., Belmonte, A., Bechi, N., Realacci, M., et al. (2006). Macrophage migration inhibitory factor-nitric oxide interaction in human fetal membranes at term pregnancy. JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 13(4), 263-270 [10.1016/j.jsgi.2006.02.010].
Macrophage migration inhibitory factor-nitric oxide interaction in human fetal membranes at term pregnancy
Ticconi, Carlo
;Piccione, Emilio;
2006-05-01
Abstract
Macrophage migration inhibitory factor (MIF), a multifunctional proinflammatory cytokine, has been recently involved in many aspects of reproduction including pregnancy. However, no evidence is available on the role of MIF in gestational tissues nor on factors regulating MIF production. This study, conducted on explants of human fetal membranes at term gestation, has been undertaken to investigate whether: (1) MIF is produced by fetal membranes; (2) nitric oxide (NO) can regulate local MIF production; and (3) MIF, in turn, can influence NO release in these tissues.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
