In the last three decades cutaneous melanoma has been widely investigated as a steroid hormone-sensitive cancer. Following this hypothesis, many epidemiological studies have investigated the relationship between estrogens and melanoma. No evidence to date has supported this association due to the great complexity of genetic, external and environmental factors underlying the development of this cancer. Molecular mechanisms through which estrogen and their receptor exert a role in melanoma genesis are still under investigation with new studies increasingly focusing on the discovery of new molecular targets for therapeutic treatments.

Dika, E., Patrizi, A., Lambertini, M., Manuelpillai, N., Fiorentino, M., Altimari, A., et al. (2019). Estrogen receptors and melanoma: a review. CELLS, 8(11), 1463 [10.3390/cells8111463].

Estrogen receptors and melanoma: a review

Campione E.;
2019-01-01

Abstract

In the last three decades cutaneous melanoma has been widely investigated as a steroid hormone-sensitive cancer. Following this hypothesis, many epidemiological studies have investigated the relationship between estrogens and melanoma. No evidence to date has supported this association due to the great complexity of genetic, external and environmental factors underlying the development of this cancer. Molecular mechanisms through which estrogen and their receptor exert a role in melanoma genesis are still under investigation with new studies increasingly focusing on the discovery of new molecular targets for therapeutic treatments.
2019
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore MED/35 - MALATTIE CUTANEE E VENEREE
English
protein binding
receptors, estrogen
signal transduction
disease susceptibility
estrogens
melanoma
woman
animals
estrogens
humans
Dika, E., Patrizi, A., Lambertini, M., Manuelpillai, N., Fiorentino, M., Altimari, A., et al. (2019). Estrogen receptors and melanoma: a review. CELLS, 8(11), 1463 [10.3390/cells8111463].
Dika, E; Patrizi, A; Lambertini, M; Manuelpillai, N; Fiorentino, M; Altimari, A; Ferracin, M; Lauriola, M; Fabbri, E; Campione, E; Veronesi, G; Scarfi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/261145
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