Basal cell carcinoma (BCC) is the most common type of carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic and genetic factors. However, despite the progress in the field, BCC biology and mechanisms of resistance against systemic treatments have been poorly investigated. The aim of the present review is to provide a revision of BCC histological and molecular features, including microRNA (miRNA) dysregulation, with a specific focus on the molecular basis of BCC systemic therapies. Papers from the last ten years regarding BCC genetic and phenotypic alterations, as well as the mechanism of resistance against hedgehog pathway inhibitors vismodegib and sonidegib were included. The involvement of miRNAs in BCC resistance to systemic therapies is emerging as a new field of knowledge.

Dika, E., Scarfi, F., Ferracin, M., Broseghini, E., Marcelli, E., Bortolani, B., et al. (2020). Basal cell carcinoma: A comprehensive review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(15) [10.3390/ijms21155572].

Basal cell carcinoma: A comprehensive review

Campione E.;
2020-01-01

Abstract

Basal cell carcinoma (BCC) is the most common type of carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic and genetic factors. However, despite the progress in the field, BCC biology and mechanisms of resistance against systemic treatments have been poorly investigated. The aim of the present review is to provide a revision of BCC histological and molecular features, including microRNA (miRNA) dysregulation, with a specific focus on the molecular basis of BCC systemic therapies. Papers from the last ten years regarding BCC genetic and phenotypic alterations, as well as the mechanism of resistance against hedgehog pathway inhibitors vismodegib and sonidegib were included. The involvement of miRNAs in BCC resistance to systemic therapies is emerging as a new field of knowledge.
2020
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore MED/35 - MALATTIE CUTANEE E VENEREE
English
basal cell carcinoma
genetic
hedgehog pathway inhibitors
microRNA
sonidegib
treatment
vismodegib
Dika, E., Scarfi, F., Ferracin, M., Broseghini, E., Marcelli, E., Bortolani, B., et al. (2020). Basal cell carcinoma: A comprehensive review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(15) [10.3390/ijms21155572].
Dika, E; Scarfi, F; Ferracin, M; Broseghini, E; Marcelli, E; Bortolani, B; Campione, E; Riefolo, M; Ricci, C; Lambertini, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/261137
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