The positive effects of physical activity on cognitive functions are widely known. Aerobic training is known to promote the expression of neurotrophins, thus inducing an increase in the development and survival of neurons, as well as enhancing synaptic plasticity. Based on this evidence, in the present study, we analyze the effects of two different types of aerobic training, progressive continuous (PC) and varying continuous (VC), on synaptic and muscular plasticity in heterozygous mice carrying the genetic mutation for Niemann-Pick type C disease. We also analyze the effects on synaptic plasticity by extracellular recordings in vitro in mouse hippocampal slices, while the morphological structure of muscle tissue was studied by transmission electron microscopy. Our results show a modulation of synaptic plasticity that varies according to the type of training protocol used, and only the VC protocol administered twice a week, has a significantly positive effect on long-term potentiation. On the contrary, ultrastructural analysis of muscle tissue shows an improvement in cellular conditions in all trained mice. These results confirm the beneficial effects of exercise on quality of life, supporting the hypothesis that physical activity could represent an alternative therapeutic strategy for patients with Niemann-Pick type C disease.

Cariati, I., Scimeca, M., Tancredi, V., Grazia D’Amico, A., Pallone, G., Palmieri, M., et al. (2020). Effects of Different Continuous Aerobic Training Protocols in a Heterozygous Mouse Model of Niemann-Pick Type C Disease. JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY, 5(3), 1-9 [10.3390/jfmk5030053].

Effects of Different Continuous Aerobic Training Protocols in a Heterozygous Mouse Model of Niemann-Pick Type C Disease

Ida Cariati;Manuel Scimeca;Virginia Tancredi;Giovanna D’Arcangelo
2020-07-18

Abstract

The positive effects of physical activity on cognitive functions are widely known. Aerobic training is known to promote the expression of neurotrophins, thus inducing an increase in the development and survival of neurons, as well as enhancing synaptic plasticity. Based on this evidence, in the present study, we analyze the effects of two different types of aerobic training, progressive continuous (PC) and varying continuous (VC), on synaptic and muscular plasticity in heterozygous mice carrying the genetic mutation for Niemann-Pick type C disease. We also analyze the effects on synaptic plasticity by extracellular recordings in vitro in mouse hippocampal slices, while the morphological structure of muscle tissue was studied by transmission electron microscopy. Our results show a modulation of synaptic plasticity that varies according to the type of training protocol used, and only the VC protocol administered twice a week, has a significantly positive effect on long-term potentiation. On the contrary, ultrastructural analysis of muscle tissue shows an improvement in cellular conditions in all trained mice. These results confirm the beneficial effects of exercise on quality of life, supporting the hypothesis that physical activity could represent an alternative therapeutic strategy for patients with Niemann-Pick type C disease.
18-lug-2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/01 - STATISTICA MEDICA
Settore M-EDF/02 - METODI E DIDATTICHE DELLE ATTIVITA' SPORTIVE
Settore BIO/09
English
Con Impact Factor ISI
Cariati, I., Scimeca, M., Tancredi, V., Grazia D’Amico, A., Pallone, G., Palmieri, M., et al. (2020). Effects of Different Continuous Aerobic Training Protocols in a Heterozygous Mouse Model of Niemann-Pick Type C Disease. JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY, 5(3), 1-9 [10.3390/jfmk5030053].
Cariati, I; Scimeca, M; Tancredi, V; Grazia D’Amico, A; Pallone, G; Palmieri, M; Frank, C; D’Arcangelo, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/261030
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