Our pharmacogenomic study evaluated the influence of the presence/absence of genetic variants of psoriasis-risk loci on the clinical response to secukinumab. Differences in the single-nucleotide polymorphism (SNP) pattern characterizing HLA-Cw6+ or HLA-Cw6- patient subpopulations, showing high or low responses to secukinumab, were also analysed.

Morelli, M., Galluzzo, M., Madonna, S., Scarponi, C., Scaglione, G.l., Galluccio, T., et al. (2021). HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58 and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis. EXPERT OPINION ON BIOLOGICAL THERAPY, 21(2), 259-270 [10.1080/14712598.2021.1862082].

HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58 and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis

Galluzzo, Marco;Bianchi, Luca;Talamonti, Marina;
2021-01-01

Abstract

Our pharmacogenomic study evaluated the influence of the presence/absence of genetic variants of psoriasis-risk loci on the clinical response to secukinumab. Differences in the single-nucleotide polymorphism (SNP) pattern characterizing HLA-Cw6+ or HLA-Cw6- patient subpopulations, showing high or low responses to secukinumab, were also analysed.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/35 - MALATTIE CUTANEE E VENEREE
English
Con Impact Factor ISI
HLA-Cw6; Psoriasis; SNPs; anti-IL-17A; pharmacogenomics; secukinumab
Morelli, M., Galluzzo, M., Madonna, S., Scarponi, C., Scaglione, G.l., Galluccio, T., et al. (2021). HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58 and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis. EXPERT OPINION ON BIOLOGICAL THERAPY, 21(2), 259-270 [10.1080/14712598.2021.1862082].
Morelli, M; Galluzzo, M; Madonna, S; Scarponi, C; Scaglione, Gl; Galluccio, T; Andreani, M; Pallotta, S; Girolomoni, G; Bianchi, L; Talamonti, M; Albanesi, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/260562
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