The aim of the present review is to discuss the potential link between RAS, BRAF and microsatellite instability (MSI) mutational patterns and chemotherapeutic agent efficacy [Irinotecan (IRI) vs. Oxaliplatin (OXA)], and how this can potentially influence the choice of the chemotherapy backbone.

Morelli, C., Formica, V., Riondino, S., Russo, A., Ferroni, P., Guadagni, F., et al. (2021). Irinotecan or oxaliplatin: which is the first move for the mate?. CURRENT MEDICINAL CHEMISTRY, 28(16), 3158-3172 [10.2174/0929867327666201016124950].

Irinotecan or oxaliplatin: which is the first move for the mate?

Formica, Vincenzo;Riondino, Silvia;Roselli, Mario
2021-01-01

Abstract

The aim of the present review is to discuss the potential link between RAS, BRAF and microsatellite instability (MSI) mutational patterns and chemotherapeutic agent efficacy [Irinotecan (IRI) vs. Oxaliplatin (OXA)], and how this can potentially influence the choice of the chemotherapy backbone.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/06 - ONCOLOGIA MEDICA
English
BRAF
Chemotherapy
Colorectal cancer
Irinotecan
KRAS
MSI
Molecular targets
Oxaliplatin
Morelli, C., Formica, V., Riondino, S., Russo, A., Ferroni, P., Guadagni, F., et al. (2021). Irinotecan or oxaliplatin: which is the first move for the mate?. CURRENT MEDICINAL CHEMISTRY, 28(16), 3158-3172 [10.2174/0929867327666201016124950].
Morelli, C; Formica, V; Riondino, S; Russo, A; Ferroni, P; Guadagni, F; Roselli, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/257909
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