FGFR-TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR-TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed FGFR3-TACC3 gene fusion, so screening for this mutation at diagnosis is not recommended.

Banella, C., Ginevrino, M., Catalano, G., Fabiani, E., Falconi, G., Divona, M., et al. (2020). Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration. HEMATOLOGY/ONCOLOGY AND STEM CELL THERAPY, -(-), 1-6 [10.1016/j.hemonc.2020.02.005].

Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration

Catalano, G;Falconi, G;Panetta, P;Voso, M T;Noguera, N I
2020-03-16

Abstract

FGFR-TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR-TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed FGFR3-TACC3 gene fusion, so screening for this mutation at diagnosis is not recommended.
16-mar-2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Con Impact Factor ISI
Acute myeloid leukemia
Aneuploidy
FGFR3–TACC3
Glioblastoma
Myelodysplastic syndromes
Banella, C., Ginevrino, M., Catalano, G., Fabiani, E., Falconi, G., Divona, M., et al. (2020). Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration. HEMATOLOGY/ONCOLOGY AND STEM CELL THERAPY, -(-), 1-6 [10.1016/j.hemonc.2020.02.005].
Banella, C; Ginevrino, M; Catalano, G; Fabiani, E; Falconi, G; Divona, M; Curzi, P; Panetta, P; Voso, Mt; Noguera, Ni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/257121
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