Coronaviruses (CoV) are a large family of viruses that are common in humans and many animal species. Animal coronaviruses rarely infect humans with the exceptions of the Middle East respiratory syndrome ( MERS-CoV ), the severe acute respiratory syndrome corona virus (SARS-CoV), and now SARS-CoV-2, which is the cause of the ongoing pandemic of coronavirus disease 2019 (COVID-19). Several studies suggested that genetic variants in the ACE2 gene may influence the host susceptibility or resistance to SARS-CoV-2 infection according to the functional role of ACE2 in human pathophysiology. However, many of these studies have been conducted in silico based on epidemiological and population data. We therefore investigated the occurrence of ACE2 variants in a cohort of 131 Italian unrelated individuals clinically diagnosed with COVID-19 and in an Italian control population, to evaluate a possible allelic association with COVID-19, by direct DNA analysis.
Novelli, A., Biancolella, M., Borgiani, P., Cocciadiferro, D., Colona, V.L., D'Apice, M.R., et al. (2020). Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients. HUMAN GENOMICS, 14(1), 29.
Tipologia: | Articolo su rivista |
Citazione: | Novelli, A., Biancolella, M., Borgiani, P., Cocciadiferro, D., Colona, V.L., D'Apice, M.R., et al. (2020). Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients. HUMAN GENOMICS, 14(1), 29. |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/03 |
Revisione (peer review): | Esperti anonimi |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/s40246-020-00279-z |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2020 |
Titolo: | Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients |
Autori: | |
Autori: | Novelli, A; Biancolella, M; Borgiani, P; Cocciadiferro, D; Colona, VL; D'Apice, MR; Rogliani, P; Zaffina, S; Leonardis, F; Campana, A; Raponi, M; Andreoni, M; Grelli, S; Novelli, G |
Appare nelle tipologie: | 01 - Articolo su rivista |
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