Coronaviruses (CoV) are a large family of viruses that are common in humans and many animal species. Animal coronaviruses rarely infect humans with the exceptions of the Middle East respiratory syndrome ( MERS-CoV ), the severe acute respiratory syndrome corona virus (SARS-CoV), and now SARS-CoV-2, which is the cause of the ongoing pandemic of coronavirus disease 2019 (COVID-19). Several studies suggested that genetic variants in the ACE2 gene may influence the host susceptibility or resistance to SARS-CoV-2 infection according to the functional role of ACE2 in human pathophysiology. However, many of these studies have been conducted in silico based on epidemiological and population data. We therefore investigated the occurrence of ACE2 variants in a cohort of 131 Italian unrelated individuals clinically diagnosed with COVID-19 and in an Italian control population, to evaluate a possible allelic association with COVID-19, by direct DNA analysis.

Novelli, A., Biancolella, M., Borgiani, P., Cocciadiferro, D., Colona, V.l., D'Apice, M.r., et al. (2020). Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients. HUMAN GENOMICS, 14(1), 29 [10.1186/s40246-020-00279-z].

Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients

Biancolella, Michela;Borgiani, Paola;D'Apice, Maria Rosaria;Rogliani, Paola;Leonardis, Francesca;Andreoni, Massimo;Grelli, Sandro;Novelli, Giuseppe
2020

Abstract

Coronaviruses (CoV) are a large family of viruses that are common in humans and many animal species. Animal coronaviruses rarely infect humans with the exceptions of the Middle East respiratory syndrome ( MERS-CoV ), the severe acute respiratory syndrome corona virus (SARS-CoV), and now SARS-CoV-2, which is the cause of the ongoing pandemic of coronavirus disease 2019 (COVID-19). Several studies suggested that genetic variants in the ACE2 gene may influence the host susceptibility or resistance to SARS-CoV-2 infection according to the functional role of ACE2 in human pathophysiology. However, many of these studies have been conducted in silico based on epidemiological and population data. We therefore investigated the occurrence of ACE2 variants in a cohort of 131 Italian unrelated individuals clinically diagnosed with COVID-19 and in an Italian control population, to evaluate a possible allelic association with COVID-19, by direct DNA analysis.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03
English
Adolescent
Adult
Aged
Aged, 80 and over
Betacoronavirus
Child
Computer Simulation
Coronavirus Infections
Female
Genetic Predisposition to Disease
Humans
Italy
Male
Middle Aged
Peptidyl-Dipeptidase A
Pneumonia, Viral
Whole Exome Sequencing
Young Adult
Pandemics
Novelli, A., Biancolella, M., Borgiani, P., Cocciadiferro, D., Colona, V.l., D'Apice, M.r., et al. (2020). Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients. HUMAN GENOMICS, 14(1), 29 [10.1186/s40246-020-00279-z].
Novelli, A; Biancolella, M; Borgiani, P; Cocciadiferro, D; Colona, Vl; D'Apice, Mr; Rogliani, P; Zaffina, S; Leonardis, F; Campana, A; Raponi, M; Andreoni, M; Grelli, S; Novelli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/256999
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