By retrospectively collecting data from nine Italian centres of pediatric endocrinology, we assessed the different management and final outcome of children with short stature and idiopathic delayed puberty. Data were obtained in 77 patients (54 males, 23 females) diagnosed and followed-up in the various centres during the last 15 years. Inclusion criteria were short stature at initial observation and idiopathic delayed puberty diagnosed during follow-up. At first observation, age was 13.8± 1.0 years and height standard deviation score (SDS) was –2.6±0.6 in males. In females age was 13.1±0.9 years and height SDS –2.6±0.4. Local diagnostic and therapeutic protocols included testing for growth-hormone deficiency (six centres) and treatment in case of deficiency or, in the remaining centres, testosterone or no treatment in males, and no treatment in females. At diagnosis, both in males and in females, the auxological features (height SDS, target height SDS and bone age delay) were similar in the patients treated with growth hormone, testosterone or not treated. Overall 32 patients received growth hormone (25 males, 7 females), 33 no treatment (17 males, 16 females) and 12 testosterone. There was no difference in the adult height of males and females in the different treatment groups. In males there were no differences between adult and target height SDSs (growth hormone-treated 0.31±0.79, untreated 0.10±0.82, testosterone-treated 0.05±0.95), between adult and initial height SDSs (growth hormone-treated 1.70± 0.93, untreated 1.55±0.92, testosterone-treated 1.53±1.43) and percentage of subjects with adult height above target height. In females, there were no differences between adult and target height SDSs (growth hormone-treated –0.49±1.13; untreated 0.10±0.97) and between adult and initial height SDSs (growth hormone-treated 1.76±0.92; untreated 1.77± 0.98), whereas a significantly higher percentage of patients remained below target height in the growth hormone-treated group (6/7, 85.7% vs 5/11, 31.3%) (P=0.02). In conclusion, the diagnostic and therapeutic management of the patients with short stature and delayed puberty is different among Italian pediatric endocrinologists. Our data do not support the usefulness of growth-hormone therapy in improving adult height in subjects with short stature and delayed puberty, particularly in the female sex.

Zucchini, S., Wasniewska, M., Cisternino, M., Salerno, M., Iughetti, L., Maghnie, M., et al. (2008). Adult height in children with short stature and idiopathic delayed puberty after different management. EUROPEAN JOURNAL OF PEDIATRICS, 167, 677-681.

Adult height in children with short stature and idiopathic delayed puberty after different management.

CIANFARANI, STEFANO
2008-01-01

Abstract

By retrospectively collecting data from nine Italian centres of pediatric endocrinology, we assessed the different management and final outcome of children with short stature and idiopathic delayed puberty. Data were obtained in 77 patients (54 males, 23 females) diagnosed and followed-up in the various centres during the last 15 years. Inclusion criteria were short stature at initial observation and idiopathic delayed puberty diagnosed during follow-up. At first observation, age was 13.8± 1.0 years and height standard deviation score (SDS) was –2.6±0.6 in males. In females age was 13.1±0.9 years and height SDS –2.6±0.4. Local diagnostic and therapeutic protocols included testing for growth-hormone deficiency (six centres) and treatment in case of deficiency or, in the remaining centres, testosterone or no treatment in males, and no treatment in females. At diagnosis, both in males and in females, the auxological features (height SDS, target height SDS and bone age delay) were similar in the patients treated with growth hormone, testosterone or not treated. Overall 32 patients received growth hormone (25 males, 7 females), 33 no treatment (17 males, 16 females) and 12 testosterone. There was no difference in the adult height of males and females in the different treatment groups. In males there were no differences between adult and target height SDSs (growth hormone-treated 0.31±0.79, untreated 0.10±0.82, testosterone-treated 0.05±0.95), between adult and initial height SDSs (growth hormone-treated 1.70± 0.93, untreated 1.55±0.92, testosterone-treated 1.53±1.43) and percentage of subjects with adult height above target height. In females, there were no differences between adult and target height SDSs (growth hormone-treated –0.49±1.13; untreated 0.10±0.97) and between adult and initial height SDSs (growth hormone-treated 1.76±0.92; untreated 1.77± 0.98), whereas a significantly higher percentage of patients remained below target height in the growth hormone-treated group (6/7, 85.7% vs 5/11, 31.3%) (P=0.02). In conclusion, the diagnostic and therapeutic management of the patients with short stature and delayed puberty is different among Italian pediatric endocrinologists. Our data do not support the usefulness of growth-hormone therapy in improving adult height in subjects with short stature and delayed puberty, particularly in the female sex.
2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/13 - ENDOCRINOLOGIA
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
Delayed puberty, Short stature, Adult height, GH therapy,Testosterone
Zucchini, S., Wasniewska, M., Cisternino, M., Salerno, M., Iughetti, L., Maghnie, M., et al. (2008). Adult height in children with short stature and idiopathic delayed puberty after different management. EUROPEAN JOURNAL OF PEDIATRICS, 167, 677-681.
Zucchini, S; Wasniewska, M; Cisternino, M; Salerno, M; Iughetti, L; Maghnie, M; Street, M; Caruso Nicoletti, M; Cianfarani, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/25645
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