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EnglishA common metabolic condition for living organisms is starvation/fasting, a state that could play systemic-beneficial roles. Complex adaptive responses are activated during fasting to help the organism to maintain energy homeostasis and avoid nutrient stress. Metabolic rearrangements during fasting cause mild oxidative stress in skeletal muscle. The nuclear factor erythroid 2-related factor 2 (Nrf2) controls adaptive responses and remains the major regulator of quenching mechanisms underlying different types of stress. Here, we demonstrate a positive role of fasting as a protective mechanism against oxidative stress in skeletal muscle. In particular, by using in vivo and in vitro models of fasting, we found that typical Nrf2-dependent genes, including those controlling iron (e.g., Ho-1) and glutathione (GSH) metabolism (e.g., Gcl, Gsr) are induced along with increased levels of the glutathione peroxidase 4 (Gpx4), a GSH-dependent antioxidant enzyme. These events are associated with a significant reduction in malondialdehyde, a well-known by-product of lipid peroxidation. Our results suggest that fasting could be a valuable approach to boost the adaptive anti-oxidant responses in skeletal muscle.
Lettieri-Barbato, D., Minopoli, G., Caggiano, R., Izzo, R., Santillo, M., Aquilano, K., et al. (2020). Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(20), 1-12.
| Tipologia: | Articolo su rivista |
| Citazione: | Lettieri-Barbato, D., Minopoli, G., Caggiano, R., Izzo, R., Santillo, M., Aquilano, K., et al. (2020). Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(20), 1-12. |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore BIO/10 |
| Revisione (peer review): | Esperti anonimi |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/ijms21207780 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 21-ott-2020 |
| Titolo: | Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle |
| Autori: | |
| Autori: | Lettieri-Barbato, D; Minopoli, G; Caggiano, R; Izzo, R; Santillo, M; Aquilano, K; Faraonio, R |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 76. (2020) Lettieri-barbato et al_Int J Mol Sci.pdf | Versione Editoriale (PDF) | Copyright dell'editore | Open Access Visualizza/Apri |
http://hdl.handle.net/2108/255914
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